NDLI: Association between glutathione S-transferases M1 and T1 gene polymorphisms and prostate cancer risk: a systematic review and meta-analysis

Content Provider	Springer Nature Link
Author	Cai, Qiliang Wang, Zhun Zhang, Wei Guo, Xuemei Shang, Zhiqun Jiang, Ning Tian, Jing Niu, Yuanjie
Copyright Year	2013
Abstract	Genetic polymorphisms in glutathione S-transferases M1 (GSTM1) and T1 (GSTT1) genes have been widely reported and considered to have a significant effect on prostate cancer (PCa) risk, but the results are inconsistent. To evaluate the impact of the GSTM1 and GSTT1 polymorphism on PCa risk, we conducted a comprehensive meta-analysis based on 18 eligible studies. A total of 18 studies, including 7,119 subjects for GSTM1 and 6,454 subjects for GSTT1 between 1999 and 2012 were identified through researching MEDLINE, PubMed, Web of Science, EMBASE, Chinese National Knowledge Infrastructure database, and Chinese Biomedical Literature database. A meta-analysis was performed to obtain summary-estimated odd ratios and 95 % confidence intervals of GSTM1 and GSTT1 polymorphisms for PCa, with attention to study quality and publication bias. Overall, there is a significant association between GSTM1 (odds ratio (OR) = 1.407, 95 % confidence intervals (95 % CI) = 1.147–1.727, I $^{2}$ = 73.2 %, P = 0.001) genotypes and PCa susceptibility. Significant associations were also observed in subgroups of Caucasian populations (OR = 1.262, 95 % CI = 1.055–1.511, I $^{2}$ = 48.7 %, P = 0.011) and Asian populations (OR = 1.776, 95 % CI = 1.134–2.781, I $^{2}$ = 83.4 %, P = 0.012). However, no significant association was found (OR = 1.776, 95 % CI = 1.134–2.781, P = 0.243) in African-American populations when stratified by ethnicity. While, there was no significant association seen between GSTT1 (OR = 1.003, 95 % CI = 0.823–1.298, I $^{2}$ = 68.8 %, P = 0.778) genotypes and PCa risk. However, no significant associations were observed in subgroups of Caucasian populations (OR = 1.086, 95 % CI = 0.801–1.471, I $^{2}$ = 72.1 %, P = 0.597) and Asian populations (OR = 0.961, 95 % CI = 0.644–1.434, I $^{2}$ = 73.0 %, P = 0.846), and similar result was found among African-American populations (OR = 0.802, 95 % CI = 0.194–3.321, P = 0.761) when stratified by ethnicity. Our results suggest that the GSTM1 gene polymorphism contributes to PCa susceptibility, while GSTT1 gene polymorphism is not associated with PCa in our study.
Starting Page	247
Ending Page	256
Page Count	10
File Format	PDF
ISSN	10104283
Journal	Tumor Biology
Volume Number	35
Issue Number	1
e-ISSN	14230380
Language	English
Publisher	Springer Netherlands
Publisher Date	2013-07-26
Publisher Place	Dordrecht
Access Restriction	Subscribed
Subject Keyword	Glutathione S-transferases M1 Glutathione S-transferases T1 polymorphism Prostate cancer Meta-analysis Molecular epidemiology Cancer Research
Content Type	Text
Resource Type	Article
Subject	Medicine Cancer Research

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