NDLI: Usefulness of the neutrophil-to-lymphocyte ratio in predicting lymph node metastasis in patients with non-small cell lung cancer

Content Provider	Springer Nature Link
Author	Huang, Chongbiao Yue, Jie Li, Zengxun Li, Na Zhao, Jinkun Qi, Daliang
Copyright Year	2015
Abstract	Preoperative neutrophil-to-lymphocyte ratio (NLR) is a new hotspot for its prognostic significance in many types of cancers. In this study, a novel diagnosing model—the combination of enhanced contrast computed tomography (ECCT) and NLR (COCT-NLR) was constructed to detect the lymph nodal involvement in patients with non-small cell lung cancer (NSCLC). The clinicopathological parameters and thoracic ECCT images of 353 NSCLC patients were retrospectively reviewed. The COCT-NLR model was constructed and evaluated in detecting regional lymph nodal metastasis in patients with NSCLC. Univariate and multivariate analyses of clinicopathological parameters revealed that NLR value was independently associated with regional nodal involvement rate in patients with NSCLC (odds ratio (OR) = 4.770; 95 % confidence interval (CI), 2.487–9.146; P < 0.001). Compared with ECCT and NLR, the COCT-NLR model showed the highest efficacy in predicting nodal involvement. The sensitivity and specificity of COCT-NLR were 70.59 and 74.89 %, respectively. The COCT-NLR model is a valuable tool in detecting regional lymph node metastasis in patients with NSCLC.
Starting Page	7581
Ending Page	7589
Page Count	9
File Format	PDF
ISSN	10104283
Journal	Tumor Biology
Volume Number	36
Issue Number	10
e-ISSN	14230380
Language	English
Publisher	Springer Netherlands
Publisher Date	2015-04-29
Publisher Place	Dordrecht
Access Restriction	Subscribed
Subject Keyword	Neutrophil-to-lymphocyte ratio Enhanced contrast computed tomography Non-small cell lung cancer Lymph node metastasis Inflammation Cancer Research
Content Type	Text
Resource Type	Article
Subject	Medicine Cancer Research

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