NDLI: Prognostic value of several biomarkers for the patients with malignant pleural mesothelioma

Content Provider	Springer Nature Link
Author	Liu, Hui Wu, Licun Ji, Kai Wang, Wei
Copyright Year	2015
Abstract	Malignant pleural mesothelioma (MPM) is a highly aggressive tumor of the pleura closely related to asbestos exposure. Rare as it is, the incidence of MPM is predicted to increase mainly as a result of a lengthy latency period from the initial asbestos exposure, making it a public health concern for the next decades. Moreover, the patients with MPM have an extremely poor prognosis due to its high resistance to conventional oncologic treatments and delayed diagnosis. Although the result of current therapeutic modalities based on patient features and clinical stages is very frustrating, great advances have been shown in the knowledge of molecular biology of MPM in recent years. This is accompanied by dozens of putative prognostic biomarkers that are actively involved in tumor biological activities. These prognostic candidates can offer us a new insight into the biological characteristics of MPM, contributing to development of individualized therapeutic strategies directed against oncogenesis and tumor progression. Thus, personalized approaches based on the molecular biology of the patient’s tissue or body fluid will potentially improve the present disappointing outcome, bringing new hope for patients with MPM. This article reviews the principal and several novel biomarkers that can have an influence on prognosis, in the hope that they can provide us with a more profound understanding of the biology of this lethal disease.
Starting Page	7375
Ending Page	7384
Page Count	10
File Format	PDF
ISSN	10104283
Journal	Tumor Biology
Volume Number	36
Issue Number	10
e-ISSN	14230380
Language	English
Publisher	Springer Netherlands
Publisher Date	2015-09-11
Publisher Place	Dordrecht
Access Restriction	Subscribed
Subject Keyword	Malignant pleural mesothelioma Biomarkers Prognosis Biology Cancer Research
Content Type	Text
Resource Type	Article
Subject	Medicine Cancer Research

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