NDLI: MicroRNA expression profiles in muscle-invasive bladder cancer: identification of a four-microRNA signature associated with patient survival

Content Provider	Springer Nature Link
Author	Xu, Zheng Yu, Yan Qiu Ge, Yu Zheng Zhu, Jia Geng Zhu, Meng Zhao, You Cai Xu, Lu Wei Yang, Xiao Bing Geng, Li Guo Dou, Quan Liang Jia, Rui Peng
Copyright Year	2015
Abstract	Bladder cancer ranks the second most common genitourinary tract cancer, and muscle-invasive bladder cancer (MIBC) accounts for approximately 25 % of all bladder cancer cases with high mortality. In the current study, with a total of 202 treatment-naïve primary MIBC patients identified from The Cancer Genome Atlas dataset, we comprehensively analyzed the genome-wide microRNA (miRNA) expression profiles in MIBC, with the aim to investigate the relationship of miRNA expression with the progression and prognosis of MIBC, and generate a miRNA signature of prognostic capabilities. In the progression-related miRNA profiles, a total of 47, 16, 3, and 84 miRNAs were selected for pathologic T, N, M, and histologic grade, respectively. Of the eight most important progression-related miRNAs, four (let-7c, mir-125b-1, mir-193a, and mir-99a) were significantly associated with survival of patients with MIBC. Finally, a four-miRNA signature was generated and proven as a promising prognostic parameter. In summary, this study identified the specific miRNAs associated with the progression and aggressiveness of MIBC and a four-miRNA signature as a promising prognostic parameter of MIBC.
Starting Page	8159
Ending Page	8166
Page Count	8
File Format	PDF
ISSN	10104283
Journal	Tumor Biology
Volume Number	36
Issue Number	10
e-ISSN	14230380
Language	English
Publisher	Springer Netherlands
Publisher Date	2015-05-20
Publisher Place	Dordrecht
Access Restriction	Subscribed
Subject Keyword	Muscle-invasive bladder cancer microRNA Biomarker Prognosis Cancer Research
Content Type	Text
Resource Type	Article
Subject	Medicine Cancer Research

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