NDLI: Role of epithelial to mesenchymal transition proteins in gynecological cancers: pathological and therapeutic perspectives

Content Provider	Springer Nature Link
Author	Zhou, Xiao mei Zhang, Hai Han, Xia
Copyright Year	2014
Abstract	Gynecorelogic cancers like ovarian, cervical, and endometrial cancers are among the major threats to modern life, especially to female health. Like some other types of cancers, all of these gynecological cancers have found to be associated with the developmental stage epithelial to mesenchymal transition (EMT). More specifically, the aberrant expression of major EMT markers, such as lower expressions of E-cadherin and alpha-catenin, and overexpressions of N-cadherin, beta-catenin, vimentin, and matrix metalloproteinases, have been reported in ovarian, cervical, and endometrial cancers. The transcription factors, such as Twist, Snail, Slug, and Zeb, which regulate these EMT mediators, are also reported to be overexpressed in gynecological cancers. In addition to the over/lower expression, the promoter methylation of some of these genes has been identified too. In the era of target-specific cancer therapeutics, some promising studies showed that targeting EMT markers might be an interesting and successful tool in future cancer therapy. In this study, we have reviewed the recent development in the research on the association of EMT markers with three major gynecological cancers in the perspectives of carcinogenesis and therapeutics.
Starting Page	9523
Ending Page	9530
Page Count	8
File Format	PDF
ISSN	10104283
Journal	Tumor Biology
Volume Number	35
Issue Number	10
e-ISSN	14230380
Language	English
Publisher	Springer Netherlands
Publisher Date	2014-08-29
Publisher Place	Dordrecht
Access Restriction	Subscribed
Subject Keyword	Ovarian cancer Cervical cancer Endometrial cancer Epithelial to mesenchymal transitions Transcription factors Target-specific cancer therapy Cancer Research
Content Type	Text
Resource Type	Article
Subject	Medicine Cancer Research

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Role of epithelial to mesenchymal transition proteins in gynecological cancers: pathological and therapeutic perspectives.

Expression of selected epithelial–mesenchymal transition transcription factors in serous borderline ovarian tumors and type I ovarian cancers

The Role of Cytokines in Epithelial-Mesenchymal Transition in Gynaecological Cancers: A Systematic Review.

The role of TWIST1 in epithelial-mesenchymal transition and cancers

Epithelial to mesenchymal transition inducing transcription factors and metastatic cancer.

Epithelial-to-Mesenchymal Transition in the Female Reproductive Tract: From Normal Functioning to Disease Pathology

Role of slug transcription factor in promoting epithelial to mesenchymal transition in ovarian cancer

Promoter polymorphism of FASL confers protection against female-specific cancers and those of FAS impact the cancers divergently

Long non-coding RNAs as emerging regulators of epithelial to mesenchymal transition in gynecologic cancers

Role of epithelial to mesenchymal transition proteins in gynecological cancers: pathological and therapeutic perspectives

Similar Documents

Role of epithelial to mesenchymal transition proteins in gynecological cancers: pathological and therapeutic perspectives.

Expression of selected epithelial–mesenchymal transition transcription factors in serous borderline ovarian tumors and type I ovarian cancers

The Role of Cytokines in Epithelial-Mesenchymal Transition in Gynaecological Cancers: A Systematic Review.

The role of TWIST1 in epithelial-mesenchymal transition and cancers

Epithelial to mesenchymal transition inducing transcription factors and metastatic cancer.

Epithelial-to-Mesenchymal Transition in the Female Reproductive Tract: From Normal Functioning to Disease Pathology

Role of slug transcription factor in promoting epithelial to mesenchymal transition in ovarian cancer

Promoter polymorphism of FASL confers protection against female-specific cancers and those of FAS impact the cancers divergently

Long non-coding RNAs as emerging regulators of epithelial to mesenchymal transition in gynecologic cancers

Role of epithelial to mesenchymal transition proteins in gynecological cancers: pathological and therapeutic perspectives