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| Content Provider | Springer Nature Link |
|---|---|
| Author | Cao, Lei Tan, Lan Wang, Hui Fu Jiang, Teng Zhu, Xi Chen Lu, Huan Tan, Meng Shan Yu, Jin Tai |
| Copyright Year | 2015 |
| Abstract | Dietary patterns and some dietary components have been linked with dementia. We therefore performed a meta-analysis of available studies to determine whether there is an association between diet and risk of dementia. We included eligible articles and estimated risk ratio (RR) with 95 % confidence intervals (95 % CIs). Finally, there were 43 trials that met the inclusion standard. Some food intake was related with decrease of dementia, such as unsaturated fatty acids (RR: 0.84, 95 % CI: [0.74–0.95], P = 0.006), antioxidants (RR: 0.87, 95 % CI: [0.77–0.98], P = 0.026), vitamin B (RR: 0.72, 95 % CI: [0.54–0.96], P = 0.026), and the Mediterranean diet (MeDi) (RR: 0.69, 95 % CI: [0.57–0.84], P < 0.001). Some material intakes were related with increase of dementia, such as aluminum (RR: 2.24, 95 % CI: [1.49–3.37], P < 0.001), smoking (RR: 1.43, 95 % CI: [1.15–1.77], P = 0.001), and low levels of vitamin D (RR: 1.52, 95 % CI: [1.17–1.98], P = 0.002). The effect of some materials needs further investigation, such as fish (RR: 0.79, 95 % CI: [0.59–1.06], P = 0.113), vegetables and fruits (RR: 0.46, 95 % CI: [0.16–1.32], P = 0.149), and alcohol (RR: 0.74, 95 % CI: [0.55- 1.01], P = 0.056). Thus, the MeDi and higher consumption of unsaturated fatty acids, antioxidants, and B vitamins decrease the risk of dementia while smoking and higher consumption of aluminum increase the risk of dementia. Low levels of vitamin D were associated with cognitive decline. The effect of fish, vegetables, fruits, and alcohol needs further investigation. The findings will be of great significance to guide people to prevent dementia. |
| Starting Page | 6144 |
| Ending Page | 6154 |
| Page Count | 11 |
| File Format | |
| ISSN | 08937648 |
| Journal | Molecular Neurobiology |
| Volume Number | 53 |
| Issue Number | 9 |
| e-ISSN | 15591182 |
| Language | English |
| Publisher | Springer US |
| Publisher Date | 2015-11-09 |
| Publisher Place | New York |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Alzheimer’s disease Dementia Dietary patterns Diet The Mediterranean diet Meta-analysis Neurosciences Neurobiology Cell Biology Neurology |
| Content Type | Text |
| Resource Type | Article |
| Subject | Neurology Cellular and Molecular Neuroscience |
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