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| Content Provider | Springer Nature Link |
|---|---|
| Author | Lv, Qiongying Zhang, Juan Yi, Yuexiong Huang, Yue Wang, Yong Wang, Yijun Zhang, Wei |
| Copyright Year | 2015 |
| Abstract | Proliferating cell nuclear antigen (PCNA) is reported as a famous marker in various tumors. A couple of articles have been published about the clinical function of PCNA on cancer progression; however, these results are conflicting in some degree. Thus, it is crucial to perform a systematic review and meta-analysis to identify their real actions. Here, we took cervical cancer and glioma as example and then pooled hazard ratios (HRs) or odds ratios (ORs) with 95 % confidence intervals (95 % CIs). In the present study, the PCNA expression in cervical cancer and gliomas patients was both correlated with 5-year-overall survival (OS) (HR = 4.41, 95 % CI 2.71–7.17, p = 0.000; HR = 4.40, 95 % CI 3.00–6.47, p = 0.000; respectively). In addition, a fixed effect model revealed a significant association between PCNA and FIGO stage (OR = 4.48, 95 % CI 3.48–5.77, p = 0.000) or WHO grade (OR = 5.64, 95 % CI 4.15–7.68, p = 0.000), rather than age (OR = 1.01, 95 % CI 0.71–1.43, p = 0.957; OR = 1.00, 95 % CI 0.80–1.24, p = 0.989; respectively). No heterogeneity was observed across all studies. According to funnel plot, no publication bias was reported. In conclusion, our systematic review suggests that PCNA expression is significantly associated with poor 5-year survival, advanced stage or higher WHO grade, which might be suggested as a useful prognostic and diagnostic biomarker, or an effective therapy target in cervical cancer, gliomas, or even more cancers. |
| Starting Page | 6209 |
| Ending Page | 6217 |
| Page Count | 9 |
| File Format | |
| ISSN | 08937648 |
| Journal | Molecular Neurobiology |
| Volume Number | 53 |
| Issue Number | 9 |
| e-ISSN | 15591182 |
| Language | English |
| Publisher | Springer US |
| Publisher Date | 2015-11-12 |
| Publisher Place | New York |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | PCNA Prognosis Diagnosis Systematic review Neurosciences Neurobiology Cell Biology Neurology |
| Content Type | Text |
| Resource Type | Article |
| Subject | Neurology Cellular and Molecular Neuroscience |
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