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| Content Provider | Springer Nature Link |
|---|---|
| Author | Veiko, N. N. Korova, I. L. Neverova, M. E. Fidelina, O. V. Mkrtumova, N. A. Ershova, E. S. Kon’kova, M. S. Postv, A. Yu. |
| Copyright Year | 2010 |
| Abstract | In this study we have investigated properties of blood plasma extracellular DNA (cell-free DNA, cfDNA) from patients with essential arterial hypertension (AH). Concentration of cell-free DNA was basically the same as in healthy donors, however, the content of the marker, CpG-rich cell-free DNA fragments (CpG-DNA) of the transcribed area of the ribosomal repeat (TArDNA, CpG-DNA) was higher in AH patients. For evaluation of the effect of CpG-DNA on the development of arterial hypertension 2-day-old SHR rat pups and corresponding controls of normotensive WKY rats received a single subcutaneous injection of human TArDNA (700 ng) to generate anti-CpG-DNA antibodies (and thus to alter the CpG-DNA content in total cfDNA). After 9 weeks blood pressure (BP) in SHR rats immunized with CpG-DNA was significantly lower than in control SHR rats and was basically the same as in WKY rats. However, subsequently, BP of the immunized SHR exhibited age-related increase, which reached the stably high values typical for mature SHR 8 weeks later compared with control SHR. Analysis of cfDNA has shown that in 17-week-old immunized SHR rats concentrations of cell-free DNA and its small DNA fragments are lower and the content of CpG-DNA (rat TArDNA) is higher than in corresponding controls. These changes were accompanied by a 3.5-fold increase in blood endonuclease activity and the decrease in content of free (unbound to cfDNA) anti-CpG-DNA antibodies. Total content of anti-CpG-DNA antibodies in the immunized rats was the same as in control animals. Thus, the delayed age-related increase in stable BP observed in immunized SHR rats is obviously not associated with increased generation of anti-CpG-DNA antibodies. Possible reasons of this effect are discussed. |
| Starting Page | 269 |
| Ending Page | 278 |
| Page Count | 10 |
| File Format | |
| ISSN | 19907508 |
| Journal | Biochemistry (Moscow) Supplement Series B: Biomedical Chemistry |
| Volume Number | 4 |
| Issue Number | 3 |
| e-ISSN | 19907516 |
| Language | English |
| Publisher | SP MAIK Nauka/Interperiodica |
| Publisher Date | 2010-08-19 |
| Publisher Place | Dordrecht |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | ribosomal genes cell-free DNA arterial hypertension SHR WKY DNA antibodies Medicinal Chemistry Bioorganic Chemistry |
| Content Type | Text |
| Resource Type | Article |
| Subject | Biochemistry Clinical Biochemistry Molecular Medicine |
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