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| Content Provider | Springer Nature Link |
|---|---|
| Author | Maltsev, A. V. Galzitskaya, O. V. |
| Copyright Year | 2010 |
| Abstract | Studies of neurodegenerative disorders attract much attention of the world scientific community due to increasing dissemination of Alzheimer’s disease. The reason for such pathologies consists in transition of a “healthy” molecule or peptide from its native conformation into a very stable “pathological” form. During this process, molecules existing in the “pathological” conformation aggregate and form amyloid fibrils that can undergo an uncontrolled increase. Novel knowledge is required on sporadic forms of Alzheimer’s disease, on the nature of triggering mechanisms of the conformational transitions of beta-amyloid fragments from normally functioning proteins into new structure, nano-beta-amyloids, that escape of neuronal and whole-body control resulted in the loss of neurons. This review summarized results of studies on the formation of amyloid fibrils and their role in pathogenesis of amyloid diseases. |
| Starting Page | 228 |
| Ending Page | 236 |
| Page Count | 9 |
| File Format | |
| ISSN | 19907508 |
| Journal | Biochemistry (Moscow) Supplement Series B: Biomedical Chemistry |
| Volume Number | 4 |
| Issue Number | 3 |
| e-ISSN | 19907516 |
| Language | English |
| Publisher | SP MAIK Nauka/Interperiodica |
| Publisher Date | 2010-08-19 |
| Publisher Place | Dordrecht |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Alzheimer’s disease beta-amyloid amyloid fibril structure kinetics of fibril formation Medicinal Chemistry Bioorganic Chemistry |
| Content Type | Text |
| Resource Type | Article |
| Subject | Biochemistry Clinical Biochemistry Molecular Medicine |
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