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  1. Biochemistry (Moscow) Supplement Series B: Biomedical Chemistry
  2. Biochemistry (Moscow) Supplement Series B: Biomedical Chemistry : Volume 4
  3. Biochemistry (Moscow) Supplement Series B: Biomedical Chemistry : Volume 4, Issue 3, September 2010
  4. A mechanism of the toxicity of artificial ribonucleases for human cancer cells
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Biochemistry (Moscow) Supplement Series B: Biomedical Chemistry : Volume 11
Biochemistry (Moscow) Supplement Series B: Biomedical Chemistry : Volume 10
Biochemistry (Moscow) Supplement Series B: Biomedical Chemistry : Volume 9
Biochemistry (Moscow) Supplement Series B: Biomedical Chemistry : Volume 8
Biochemistry (Moscow) Supplement Series B: Biomedical Chemistry : Volume 7
Biochemistry (Moscow) Supplement Series B: Biomedical Chemistry : Volume 6
Biochemistry (Moscow) Supplement Series B: Biomedical Chemistry : Volume 5
Biochemistry (Moscow) Supplement Series B: Biomedical Chemistry : Volume 4
Biochemistry (Moscow) Supplement Series B: Biomedical Chemistry : Volume 4, Issue 4, December 2010
Biochemistry (Moscow) Supplement Series B: Biomedical Chemistry : Volume 4, Issue 3, September 2010
Genetic variations in the regulation of energy balance
The nuclear glutathione and its functions
Formation and participation of nano-amyloids in pathogenesis of Alzheimer’s disease and other amyloidogenic diseases
Electrochemical immunoanalysis of cardiac myoglobin
Microencapsulated multicellular tumor spheroids as a novel in vitro model for drug screening
Regulation of cholesterol biosynthesis and metabolism in Hep G2 cells by Δ8(14)-15-ketoergostane derivatives
A decrease in the sensitivity of adenylyl cyclase and heterotrimeric g proteins to chorionic gonadotrophin and peptide hormones action in the tissues of reproductive system of rats with experimental type 2 diabetes
Hepatotoxic effects of acetaminophen. Protective properties of tryptophan derivatives
The effect of CpG-rich DNA fragments on the development of hypertension in spontaneously hypertensive rats (SHR)
A mechanism of the toxicity of artificial ribonucleases for human cancer cells
Determination of total aminothiols and neuroactive amino acids in plasma by high performance liquid chromatography with fluorescence detection
An approach to the identification of molecular fractions of human erythrocyte phospholipids using HPLC with mass-spectrometric detection
Preparation of affinity sorbents with immobilized synthetic ligands for therapeutic apheresis
Biochemistry (Moscow) Supplement Series B: Biomedical Chemistry : Volume 4, Issue 2, June 2010
Biochemistry (Moscow) Supplement Series B: Biomedical Chemistry : Volume 4, Issue 1, March 2010
Biochemistry (Moscow) Supplement Series B: Biomedical Chemistry : Volume 3
Biochemistry (Moscow) Supplement Series B: Biomedical Chemistry : Volume 2
Biochemistry (Moscow) Supplement Series B: Biomedical Chemistry : Volume 1

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A mechanism of the toxicity of artificial ribonucleases for human cancer cells

Content Provider Springer Nature Link
Author Logashenko, E. B. Kuznetsova, I. L. Ryabchikova, E. I. Vlassov, V. V. Zenkova, M. A.
Copyright Year 2010
Abstract The ability of artificial ribonucleases, low molecular weight compounds exhibiting RNA cleavage in vitro, to cause human cancer cell death in a concentration-dependent manner has been studied. The cytotoxic effect of artificial ribonucleases on cells appeared at rather low concentrations of these compounds (10$^{−5}$ M). The study of mechanisms of the cytotoxic effect has shown that in addition to ribonuclease activity these compounds exhibit membranotropic activity. This activity allows the compounds to penetrate effectively inside cells. The cytotoxic effect of artificial ribonucleases involves damage of cell membrane, detachment of plasmalemma and impairments of its macromolecular organization. However, in the case of shortterm exposure to these compounds, cells survive even with damaged membrane.
Starting Page 279
Ending Page 287
Page Count 9
File Format PDF
ISSN 19907508
Journal Biochemistry (Moscow) Supplement Series B: Biomedical Chemistry
Volume Number 4
Issue Number 3
e-ISSN 19907516
Language English
Publisher SP MAIK Nauka/Interperiodica
Publisher Date 2010-08-19
Publisher Place Dordrecht
Access Restriction One Nation One Subscription (ONOS)
Subject Keyword artificial ribonucleases citotoxicity membranotropic activity antineoplastic drugs Medicinal Chemistry Bioorganic Chemistry
Content Type Text
Resource Type Article
Subject Biochemistry Clinical Biochemistry Molecular Medicine
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