| Content Provider |
World Health Organization (WHO)-Global Index Medicus |
| Author |
Jiang, Haiqiang Shen, Zhenzhen Chu, Yanjun Li, Yunlun Li, Jihua Wang, Xiaoming Yang, Wenqing Zhang, Xinya Ju, Jianqing Xu, Jingwen Yang, Chuanhua |
| Description |
Country affiliation: China Author Affiliation: Jiang H ( Experimental center of Shandong University of Traditional Chinese Medicine, Jinan 250355, China.); Shen Z ( Shandong University of Traditional Chinese Medicine, Jinan 250355, Shandong, China.); Chu Y ( Shandong University of Traditional Chinese Medicine, Jinan 250355, Shandong, China.); Li Y ( Traditional Chinese Medicine Clinical Research Base for Hypertension of Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Wenhua Xi Road, Jinan 250011, China); Li J ( Experimental center of Shandong University of Traditional Chinese Medicine, Jinan 250355, China.); Wang X ( Shandong University of Traditional Chinese Medicine, Jinan 250355, Shandong, China.); Yang W ( Shandong University of Traditional Chinese Medicine, Jinan 250355, Shandong, China.); Zhang X ( Shandong University of Traditional Chinese Medicine, Jinan 250355, Shandong, China.); Ju J ( Shandong University of Traditional Chinese Medicine, Jinan 250355, Shandong, China.); Xu J ( Shandong University of Traditional Chinese Medicine, Jinan 250355, Shandong, China.); Yang C ( Traditional Chinese Medicine Clinical Research Base for Hypertension of Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Wenhua Xi Road, Jinan 250011, China.) |
| Abstract |
A HPLC/TOF-MS-based metabolomic study was conducted to investigate the holistic therapeutic effects of Tengfu Jiangya Tablet (TJT) on spontaneously hypertensive rats (SHRs). The SHRs were divided into valsartan (VST) group, TJT group and model group, in addition, the Wistar-Kyoto rats (WKY) were taken as normal control. Serum samples were separated and identified by HPLC/TOF-MS, while the obtained data was further processed by partial least-squares discriminant analysis (PLS-DA). A clear cluster among the four groups was observed, and we identified thirteen biomarkers involved involved in sphingolipid metabolism (sphinganine, lysosphingomyelin, ceramide), glycerophospholipid metabolism (phosphatidylcholines, phosphatidylethanolamine, lysophosphatidylcholines), arginine and proline metabolism (l-proline, citrulline), tryptophan metabolism (xanthuiulrenic acid, l-kynurenine, l-tryptophan), arachidonic acid metabolism(leukotriene D4), and linoleic acid metabolism (gamma-linolenic acid). Altered metabolic pathways involved in impaired NO production, inflammation and vascular smooth muscle cells (VSMCs) apoptosis and proliferation, which suggesting the possible pathological state in SHRs. TJT as well as VST altered the metabolic state, suggesting a possible anti-hypertension role by improving NO production, and an extra cardiovascular protection role possibly by amelioration of inflammatory state and vascular remodeling. |
| File Format |
HTM / HTML |
| ISSN |
15700232 |
| Volume Number |
1002 |
| e-ISSN |
1873376X |
| Journal |
Journal of Chromatography B |
| Language |
English |
| Publisher |
Elsevier |
| Publisher Date |
2015-10-01 |
| Publisher Place |
Netherlands |
| Access Restriction |
One Nation One Subscription (ONOS) |
| Subject Keyword |
Discipline Analytical Chemistry Antihypertensive Agents Blood Drugs, Chinese Herbal Therapeutic Use Hypertension Drug Therapy Metabolomics Animals Metabolism Nitric Oxide Biosynthesis Rats Rats, Inbred Shr Rats, Inbred Wky Journal Article Research Support, Non-u.s. Gov't |
| Content Type |
Text |
| Resource Type |
Article |
| Subject |
Cell Biology Medicine Analytical Chemistry Clinical Biochemistry Biochemistry |
