NDLI: Gold nanoparticle aerosols for rodent inhalation and translocation studies

Content Provider	Springer Nature Link
Author	Möller, Winfried Gibson, Neil Geiser, Marianne Pokhrel, Suman Wenk, Alexander Takenaka, Shinji Schmid, Otmar Bulgheroni, Antonio Simonelli, Federica Kozempel, Jan Holzwarth, Uwe Wigge, Christoph Eigeldinger Berthou, Sylvie Mädler, Lutz Kreyling, Wolfgang G.
Copyright Year	2013
Abstract	The intensive use of nano-sized particles in many different applications necessitates studies on their risk assessment as there are still open questions on their safe handling and utilization. For reliable risk assessment, the interaction of nanoparticles (NP) with biological systems after various routes of exposure needs to be investigated using well-characterized NP. We report here on the generation of gold-NP (Au-NP) aerosols for inhalation studies with the spark ignition technique, and their characterization in terms of chemical composition, physical structure, morphology, and specific surface area, and on interaction with lung tissues and lung cells after 1 h inhalation by mice. The originally generated agglomerated Au-NP were converted into compact spherical Au-NP by thermal annealing at 600 °C, providing particles of similar mass, but different size and specific surface area. Since there are currently no translocation data available on inhaled Au-NP in the 10–50 nm diameter range, the emphasis was to generate NP as small as 20 nm for inhalation in rodents. For anticipated in vivo systemic translocation and dosimetry analyses, radiolabeled Au-NP were created by proton irradiating the gold electrodes of the spark generator, thus forming gamma ray emitting $^{195}$Au with 186 days half-life, allowing long-term biokinetic studies. The dissolution rate of $^{195}$Au from the NP was below detection limits. The highly concentrated, polydisperse Au-NP aerosol (1–2 × 10$^{7}$ NP/cm$^{3}$) proved to be constant over several hours in terms of its count median mobility diameter, its geometric standard deviation and number concentration. After collection on filters particles can be re-suspended and used for instillation or ingestion studies.
Starting Page	1
Ending Page	13
Page Count	13
File Format	PDF
ISSN	13880764
Journal	Journal of Nanoparticle Research
Volume Number	15
Issue Number	4
e-ISSN	1572896X
Language	English
Publisher	Springer Netherlands
Publisher Date	2013-03-19
Publisher Place	Dordrecht
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Gold nanoparticles Spark ignition Chain aggregate/agglomerate Proton irradiation Au-195 radiolabel X-ray diffraction Nanotechnology Inorganic Chemistry Characterization and Evaluation of Materials Physical Chemistry Optics, Optoelectronics, Plasmonics and Optical Devices
Content Type	Text
Resource Type	Article
Subject	Chemistry Nanoscience and Nanotechnology Atomic and Molecular Physics, and Optics Condensed Matter Physics Bioengineering Modeling and Simulation

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