NDLI: Dose-dependent pulmonary response of well-dispersed titanium dioxide nanoparticles following intratracheal instillation

Content Provider	Springer Nature Link
Author	Oyabu, Takako Morimoto, Yasuo Hirohashi, Masami Horie, Masari Kambara, Tatsuri Lee, Byeong Woo Hashiba, Masayoshi Mizuguchi, Yohei Myojo, Toshihiko Kuroda, Etsushi
Copyright Year	2013
Abstract	In order to investigate the relationship between pulmonary inflammation and particle clearance of nanoparticles, and also their dose dependency, we performed an instillation study of well-dispersed TiO$_{2}$ nanoparticles and examined the pulmonary inflammations, the particle clearance rate and histopathological changes. Wistar rats were intratracheally administered 0.1 mg (0.33 mg/kg), 0.2 mg (0.66 mg/kg), 1 mg (3.3 mg/kg), and 3 mg (10 mg/kg) of well-dispersed TiO$_{2}$ nanoparticles (diameter of agglomerates: 25 nm), and the pulmonary inflammation response and the amount of TiO$_{2}$ in the lung were determined from 3 days up to 12 months sequentially after the instillation. There were no increases of total cell or neutrophil counts in bronchoalveolar lavage fluid (BALF) in the 0.1 and the 0.2 mg-administered groups. On the other hand, mild infiltration of neutrophils was observed in the 1 and 3 mg-administered groups. Histopathological findings showed infiltration of neutrophils in the 1 and 3 mg-administered groups. Of special note, a granulomatous lesion including a local accumulation of TiO$_{2}$ was observed in the bronchioli-alveolar space in the 3 mg-administered group. The biological half times of the TiO$_{2}$ in the lung were 4.2, 4.4, 6.7, and 10.8 months in the 0.1, 0.2, 1, and 3 mg-administered groups, respectively. Neutrophil infiltration was observed as the particle clearance was delayed, suggesting that an excessive dose of TiO$_{2}$ nanoparticles may induce pulmonary inflammation and clearance delay.
Starting Page	1
Ending Page	11
Page Count	11
File Format	PDF
ISSN	13880764
Journal	Journal of Nanoparticle Research
Volume Number	15
Issue Number	4
e-ISSN	1572896X
Language	English
Publisher	Springer Netherlands
Publisher Date	2013-03-31
Publisher Place	Dordrecht
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Titanium dioxide Intratracheal instillation Inflammation Clearance Nanotechnology Inorganic Chemistry Characterization and Evaluation of Materials Physical Chemistry Optics, Optoelectronics, Plasmonics and Optical Devices
Content Type	Text
Resource Type	Article
Subject	Chemistry Nanoscience and Nanotechnology Atomic and Molecular Physics, and Optics Condensed Matter Physics Bioengineering Modeling and Simulation

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