NDLI: In vivo evaluation of Zr-based bulk metallic glass alloy intramedullary nails in rat femora

Content Provider	Springer Nature Link
Author	Imai, Kazuhiro Hiromoto, Sachiko
Copyright Year	2013
Abstract	Zr-based bulk metallic glasses (BMG) show high corrosion resistance in vitro and higher strength and lower Young’s modulus than crystalline alloys with the similar composition. This study aimed to perform an in vivo evaluation of Zr$_{65}$Al$_{7.5}$Ni$_{10}$Cu$_{17.5}$ BMG. Osteotomy of the femur was done in rats and stabilized with intramedullary nails made of Zr$_{65}$Al$_{7.5}$Ni$_{10}$Cu$_{17.5}$ BMG, Ti–6Al–4V alloy, or 316L stainless steel. Systemic and local effects of each type of nail were evaluated by measuring the levels of Cu and Ni in the blood and the surrounding soft tissue. Changes of the surface of each nail were examined by scanning electron microscopy (SEM). Healing of the osteotomy was evaluated by peripheral quantitative computed tomography and mechanical testing. No increase of Cu and Ni levels was recognized. Surface of the BMG showed no noticeable change, while Ti–6Al–4V alloy showed Ca and P deposition and 316L stainless steel showed surface irregularities and pitting by SEM observation. The stress strain index, maximum torque, torsional stiffness, and energy absorption values were larger for the BMG than those for Ti–6Al–4V alloy, although there was no significant difference. The Zr-based BMG can promote osteotomy healing as fast as Ti–6Al–4V alloy, with the possible advantage of the Zr-based BMG that bone bonding is less likely, allowing easier nail removal compared with Ti–6Al–4V alloy. The Zr-based BMG is promising for the use in osteosynthetic devices that are eventually removed.
Starting Page	759
Ending Page	768
Page Count	10
File Format	PDF
ISSN	09574530
Journal	Journal of Materials Science: Materials in Medicine
Volume Number	25
Issue Number	3
e-ISSN	15734838
Language	English
Publisher	Springer US
Publisher Date	2013-11-27
Publisher Place	Boston
Access Restriction	Subscribed
Subject Keyword	Biomaterials Polymer Sciences Ceramics, Glass, Composites, Natural Methods Metallic Materials Characterization and Evaluation of Materials Surfaces and Interfaces, Thin Films
Content Type	Text
Resource Type	Article
Subject	Biomaterials Biophysics Bioengineering Biomedical Engineering

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4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
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