NDLI: In vivo behavior of biodegradable Mg–Nd–Y–Zr

Content Provider	Springer Nature Link
Author	Aghion, E. Levy, G. Ovadia, S.
Copyright Year	2011
Abstract	The aim of the this study is to evaluate the in vivo behavior of Mg–1.5%Nd–0.5%Y–0.5%Zr implants with and without 0.4%Ca in comparison with inert Ti-6Al-4V reference implants. This was carried out by implanting cylindrical disks at the back midline of Wister male rats within the subcutaneous layer of the skin for up to 12 weeks. The degradation of magnesium-based implants in terms of hydrogen gas bubble formation was evaluated by radiography assessment; corrosion rate was analyzed by visual examination and weight loss measurements. The physiological response of the rats post-implantation was obtained by evaluating their wellbeing behavior and blood biochemical analysis including serum Mg, blood urea nitrogen, and serum creatinine. In addition, histological analyses of the soft tissue around the implants were carried out to assess local lesions relating to the implants such as inflammation, tissue necrosis, granulation, mineralization, and tumor development. The results obtained clearly indicate that apart from the normal degradation characteristics and subsequent formation of hydrogen gas bubbles, the in vivo behavior of Mg implants was adequate and comparable to that of Ti-6Al-4V reference alloy. In addition, it was evident that the corrosion degradation of the magnesium alloys was strongly related to the location of the implant within the animal’s body. The addition of 0.4%Ca improves the biodegradation corrosion resistance of the tested magnesium implants.
Starting Page	805
Ending Page	812
Page Count	8
File Format	PDF
ISSN	09574530
Journal	Journal of Materials Science: Materials in Medicine
Volume Number	23
Issue Number	3
e-ISSN	15734838
Language	English
Publisher	Springer US
Publisher Date	2011-12-22
Publisher Place	Boston
Access Restriction	Subscribed
Subject Keyword	Biomaterials Metallic Materials Ceramics, Glass, Composites, Natural Methods Polymer Sciences Surfaces and Interfaces, Thin Films Characterization and Evaluation of Materials
Content Type	Text
Resource Type	Article
Subject	Biomaterials Biophysics Bioengineering Biomedical Engineering

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