NDLI: Novel mineralized heparin–gelatin nanoparticles for potential application in tissue engineering of bone

Content Provider	Springer Nature Link
Author	Yang, Yuan Tang, Haihao Köwitsch, Alexander Mäder, Karsten Hause, Gerd Ulrich, Joachim Groth, Thomas
Copyright Year	2013
Abstract	Nanoparticles (NPs) were prepared from succinylated gelatin (s-GL) cross-linked with aldehyde heparin (a-HEP) and used subsequently as a nano-template for the mineralization of hydroxyapatite (HAP). Gelatin was functionalized with succinyl groups that made it soluble at room temperature. Heparin was oxidized to generate aldehyde groups and then used as a cross-linker that can react with s-GL to form NPs via Schiff’s base linkage. The polymer concentrations, feed molar ratios and pH conditions were varied to fabricate NPs suspension. NPs were obtained with a spheroid shape of an average size of 196 nm at pH 2.5 and 202 nm at pH 7.4. These NPs had a positive zeta potential of 7.3 ± 3.0 mV and a narrow distribution with PDI 0.123 at pH 2.5, while they had a negative zeta potential of −2.6 ± 0.3 mV and formed aggregates (PDI 0.257) at pH 7.4. The NPs prepared at pH 2.5 with a mean particle size of 196 nm were further used for mineralization studies. The mineralization process was mediated by solution without calcination at 37 °C. The HAP formed on NPs was analyzed by Fourier transform infrared spectroscopy and X-ray diffraction. HAP coated s-GL/a-HEP NPs developed in this study may be used in future as osteoinductive fillers enhancing the mechanical properties of injectable hydrogel or use as potential multifunctional device for nanotherapeutic approaches.
Starting Page	669
Ending Page	680
Page Count	12
File Format	PDF
ISSN	09574530
Journal	Journal of Materials Science: Materials in Medicine
Volume Number	25
Issue Number	3
e-ISSN	15734838
Language	English
Publisher	Springer US
Publisher Date	2013-12-06
Publisher Place	Boston
Access Restriction	Subscribed
Subject Keyword	Biomaterials Polymer Sciences Ceramics, Glass, Composites, Natural Methods Metallic Materials Characterization and Evaluation of Materials Surfaces and Interfaces, Thin Films
Content Type	Text
Resource Type	Article
Subject	Biomaterials Biophysics Bioengineering Biomedical Engineering

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Novel pHEMA-gelatin SPHs as bone scaffolds in dynamic cultures

An open-pored gelatin/hydroxyapatite composite as a potential bone substitute

An open-pored gelatin/hydroxyapatite composite as a potential bone substitute

Synthesis of gelatin-containing PHBV nanofiber mats for biomedical application

Novel electrospun polyurethane/gelatin composite meshes for vascular grafts

Orthotropic index for bone

Viscoelastic properties of mineralized alginate hydrogel beads

Mineralized collagen coatings formed by electrochemical deposition

Electrospun submicron bioactive glass fibers for bone tissue scaffold

Novel mineralized heparin–gelatin nanoparticles for potential application in tissue engineering of bone

Similar Documents

Novel pHEMA-gelatin SPHs as bone scaffolds in dynamic cultures

An open-pored gelatin/hydroxyapatite composite as a potential bone substitute

An open-pored gelatin/hydroxyapatite composite as a potential bone substitute

Synthesis of gelatin-containing PHBV nanofiber mats for biomedical application

Novel electrospun polyurethane/gelatin composite meshes for vascular grafts

Orthotropic index for bone

Viscoelastic properties of mineralized alginate hydrogel beads

Mineralized collagen coatings formed by electrochemical deposition

Electrospun submicron bioactive glass fibers for bone tissue scaffold

Novel mineralized heparin–gelatin nanoparticles for potential application in tissue engineering of bone