NDLI: Geometric adaption of biodegradable magnesium alloy scaffolds to stabilise biological myocardial grafts. Part I

Content Provider	Springer Nature Link
Author	Bauer, M. Schilling, T. Weidling, M. Hartung, D. Biskup, Ch. Wriggers, P. Wacker, F. Bach, Fr. W. Haverich, A. Hassel, T.
Copyright Year	2013
Abstract	Synthetic patch materials currently in use have major limitations, such as high susceptibility to infections and lack of contractility. Biological grafts are a novel approach to overcome these limitations, but do not always offer sufficient mechanical durability in early stages after implantation. Therefore, a stabilising structure based on resorbable magnesium alloys could support the biological graft until its physiologic remodelling. To prevent early breakage in vivo due to stress of non-determined forming, these scaffolds should be preformed according to the geometry of the targeted myocardial region. Thus, the left ventricular geometry of 28 patients was assessed via standard cardiac magnetic resonance imaging (MRI). The resulting data served as a basis for a finite element simulation (FEM). Calculated stresses and strains of flat and preformed scaffolds were evaluated. Afterwards, the structures were manufactured by abrasive waterjet cutting and preformed according to the MRI data. Finally, the mechanical durability of the preformed and flat structures was compared in an in vitro test rig. The FEM predicted higher durability of the preformed scaffolds, which was proven in the in vitro test. In conclusion, preformed scaffolds provide extended durability and will facilitate more widespread use of regenerative biological grafts for surgical left ventricular reconstruction.
Starting Page	909
Ending Page	916
Page Count	8
File Format	PDF
ISSN	09574530
Journal	Journal of Materials Science: Materials in Medicine
Volume Number	25
Issue Number	3
e-ISSN	15734838
Language	English
Publisher	Springer US
Publisher Date	2013-11-22
Publisher Place	Boston
Access Restriction	Subscribed
Subject Keyword	Biomaterials Polymer Sciences Ceramics, Glass, Composites, Natural Methods Metallic Materials Characterization and Evaluation of Materials Surfaces and Interfaces, Thin Films
Content Type	Text
Resource Type	Article
Subject	Biomaterials Biophysics Bioengineering Biomedical Engineering

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