NDLI: Synthesis of molecularly imprinted polymer as a sorbent for solid phase extraction of citalopram from human serum and urine

Content Provider	Springer Nature Link
Author	Abdouss, Majid Azodi Deilami, Saman Asadi, Ebadullah Shariatinia, Zahra
Copyright Year	2012
Abstract	This paper describes a new method for the determination of citalopram in biological fluids using molecularly imprinted solid-phase extraction as the sample cleanup technique combined with high performance liquid chromatography. The molecularly imprinted polymers were prepared using methacrylic acid as functional monomer, ethylene glycol dimethacrylate as crosslinker, chloroform as porogen and citalopram hydrobromide as the template molecule. The novel imprinted polymer was used as a solid-phase extraction sorbent for the extraction of citalopram from human serum and urine. Effective parameters on citalopram retention were studied. The optimal conditions for molecularly imprinted solid-phase extraction consisted of conditioning with 1 mL methanol and 1 mL of deionized water at neutral pH, loading of citalopram sample (50 μg L$^{−1}$) at pH 9.0, washing using 1 mL acetone and elution with 3 × 1 mL of 10 % (v/v) acetic acid in methanol. The MIP selectivity was evaluated by checking several substances with similar molecular structures to that of citalopram. Results from the HPLC analyses showed that the calibration curve of citalopram using MIP from human serum and urine is linear in the ranges of 1–100 and 2–120 μg L$^{−1}$ with good precisions (2.5 and 1.5 % for 10.0 μg L$^{−1}$), and recoveries (between 82–86 and 83–85 %), respectively.
Starting Page	1543
Ending Page	1552
Page Count	10
File Format	PDF
ISSN	09574530
Journal	Journal of Materials Science: Materials in Medicine
Volume Number	23
Issue Number	6
e-ISSN	15734838
Language	English
Publisher	Springer US
Publisher Date	2012-04-07
Publisher Place	Boston
Access Restriction	Subscribed
Subject Keyword	Metallic Materials Surfaces and Interfaces, Thin Films Polymer Sciences Biomaterials Characterization and Evaluation of Materials Ceramics, Glass, Composites, Natural Methods
Content Type	Text
Resource Type	Article
Subject	Biomaterials Biophysics Bioengineering Biomedical Engineering

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