NDLI: Development and characterization of molecularly imprinted polymers for controlled release of citalopram

Content Provider	Springer Nature Link
Author	Abdouss, Majid Asadi, Ebadullah Azodi Deilami, Saman Beik mohammadi, Neda Aslanzadeh, Saeed Amir
Copyright Year	2011
Abstract	In this work, the use of molecularly imprinted polymers (MIPs) for citalolpram as anti-depressant drug was studied. Imprinted polymers were prepared from methacrylic acid (MAA; functional monomer), ethylene glycol dimethacrylate (EGDMA; cross-linker), and citalopram (as a drug template) using bulk polymerization method. The polymeric devices were further characterized by FT-IR, thermogravimetric analysis, scanning electron microscopy, and binding experiments. The dissolution media employed in controlled release studies were hydrochloric acid at the pH level of 4.3 and phosphate buffers, at pH levels of 7.2 and 10.1, maintained at 37.0 and 25.0 ± 0.5°C. Results showed the ability of MIP polymers to control the release of citalopram. In all cases, the imprinted polymers showed a higher affinity for citalopram and a slower release rate than the nonimprinted polymers. At the pH level of 4.3 and at the temperature of 25°C, slower release of citalopram imprinted polymer occurred.
Starting Page	2273
Ending Page	2281
Page Count	9
File Format	PDF
ISSN	09574530
Journal	Journal of Materials Science: Materials in Medicine
Volume Number	22
Issue Number	10
e-ISSN	15734838
Language	English
Publisher	Springer US
Publisher Date	2011-07-21
Publisher Place	Boston
Access Restriction	Subscribed
Subject Keyword	Surfaces and Interfaces, Thin Films Characterization and Evaluation of Materials Ceramics, Glass, Composites, Natural Methods Biomaterials Metallic Materials Polymer Sciences
Content Type	Text
Resource Type	Article
Subject	Biomaterials Biophysics Bioengineering Biomedical Engineering

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