NDLI: Development of fibroblast culture in three-dimensional activated carbon fiber-based scaffold for wound healing

Content Provider	Springer Nature Link
Author	Huang, Wen Ying Yeh, Chia Lin Lin, Jui Hsiang Yang, Jai Sing Ko, Tse Hao Lin, Yu Hsin
Copyright Year	2012
Abstract	This work developed a novel bi-layer wound dressing composed of 3D activated carbon fibers that allows facilitates fibroblast cell growth and migration to a wound site for tissue reconstruction, and the gentamicin is incorporated into a poly(γ-glutamic acid)/gelatin membrane to prevent bacterial infection. In an in vitro, field emission scanning electron microscopy shows that rat skin fibroblasts appeared and spread on the surface of activated carbon fibers, and penetrated the interior and exterior of the 3D activated carbon fiber construct to a depth of roughly 200 μm. An in vivo analysis shows that fibroblast cells containing the proposed 3D scaffold had the potential of a biologically functionalized dressing to accelerate wound closure. Additionally, fibroblasts migrated to the wound site in a bi-layer wound dressing containing fibroblasts, enhancing fibronectin and type I collagen expression, resulting in faster skin regeneration than that achieved with a Tegaderm$^{™}$ hydrocolloid dressing or gauze.
Starting Page	1465
Ending Page	1478
Page Count	14
File Format	PDF
ISSN	09574530
Journal	Journal of Materials Science: Materials in Medicine
Volume Number	23
Issue Number	6
e-ISSN	15734838
Language	English
Publisher	Springer US
Publisher Date	2012-03-14
Publisher Place	Boston
Access Restriction	Subscribed
Subject Keyword	Metallic Materials Surfaces and Interfaces, Thin Films Polymer Sciences Biomaterials Characterization and Evaluation of Materials Ceramics, Glass, Composites, Natural Methods
Content Type	Text
Resource Type	Article
Subject	Biomaterials Biophysics Bioengineering Biomedical Engineering

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