NDLI: Down-Modulation of Ca2+ Channels by Endogenously Released ATP and Opioids: from the Isolated Chromaffin Cell to the Slice of Adrenal Medullae

Content Provider	Springer Nature Link
Author	Hernández, A. Segura Chama, P. Albiñana, E. Hernández Cruz, A. Hernández Guijo, J. M.
Copyright Year	2010
Abstract	Modifications in Ca2+ influx may lead to profound changes in the cell activity associated with Ca2+-dependent processes, from muscle contraction and neurotransmitter release to calcium-mediated cell death. Therefore, calcium entry into the cell requires fine regulation. In this context, understanding of the modulation of voltage-dependent Ca2+ channels seems to be critical. The modulatory process results in the enhancement or decrement of calcium influx that may regulate the local and global cytosolic Ca2+ concentrations. Here, we summarize the well-established data on this matter described in isolated chromaffin cells by our laboratory and others, and the new results we have obtained in a more physiological preparation: freshly isolated slices of mouse adrenal medullae.
Starting Page	1209
Ending Page	1216
Page Count	8
File Format	PDF
ISSN	02724340
Journal	Cellular and Molecular Neurobiology
Volume Number	30
Issue Number	8
e-ISSN	15736830
Language	English
Publisher	Springer US
Publisher Date	2010-11-16
Publisher Place	Boston
Access Restriction	Subscribed
Subject Keyword	Mouse adrenal slices Ca2+ channels Chromaffin cells Autocrine modulation Paracrine modulation ATP Methionine-enkephalin Neurobiology Cell Biology Neurosciences
Content Type	Text
Resource Type	Article
Subject	Cell Biology Medicine Cellular and Molecular Neuroscience

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Down-Modulation of Ca2+ Channels by Endogenously Released ATP and Opioids: from the Isolated Chromaffin Cell to the Slice of Adrenal Medullae