NDLI: The Coffin-Lowry Syndrome-Associated Protein rsk2 and Neurosecretion

Please wait, while we are loading the content...

Immunohistochemical and Biochemical Studies with Region-Specific Antibodies to Chromogranins A and B and Secretogranins II and III in Neuroendocrine Tumors

Inositol 1,4,5-Trisphosphate Receptor in Chromaffin Secretory Granules and Its Relation to Chromogranins

Chromogranin A and the Tumor Microenvironment

Catestatin Improves Post-Ischemic Left Ventricular Function and Decreases Ischemia/Reperfusion Injury in Heart

Chromogranins A and B as Regulators of Vesicle Cargo and Exocytosis

Chromogranin A as a Crucial Factor in the Sorting of Peptide Hormones to Secretory Granules

Ion Channels and Neuroendocrine Cells: Old Partners in the Investigation of Each Other's Function. Commentary on the “Ion Channels” Chapter

Inhibition of Ca2+ Channels and Adrenal Catecholamine Release by G Protein Coupled Receptors

Down-Modulation of Ca2+ Channels by Endogenously Released ATP and Opioids: from the Isolated Chromaffin Cell to the Slice of Adrenal Medullae

Paracrine Role of GABA in Adrenal Chromaffin Cells

Modulation of Calcium Channels by Taurine Acting Via a Metabotropic-like Glycine Receptor

Estradiol Inhibits Depolarization-Evoked Exocytosis in PC12 Cells via N-Type Voltage-Gated Calcium Channels

Comparison of Ca2+ Currents of Chromaffin Cells from Normotensive Wistar Kyoto and Spontaneously Hypertensive Rats

Structural Insights into the Function of P2X4: An ATP-Gated Cation Channel of Neuroendocrine Cells

Nanosecond Electric Pulses: A Novel Stimulus for Triggering Ca2+ Influx into Chromaffin Cells Via Voltage-Gated Ca2+ Channels

Ca2+ Dynamics in the Secretory Vesicles of Neurosecretory PC12 and INS1 Cells

Toxins that Modulate Ionic Channels as Tools for Exploring Insulin Secretion

Neuronal Calcium Sensor-1 Regulation of Calcium Channels, Secretion, and Neuronal Outgrowth

Secretion Mechanisms

In PC12 Cells, Expression of Neurosecretion and Neurite Outgrowth are Governed by the Transcription Repressor REST/NRSF

Roles of Myosin Va and Rab3D in Membrane Remodeling of Immature Secretory Granules

Munc18-1 and Syntaxin1: Unraveling the Interactions Between the Dynamic Duo

Association of SNAREs and Calcium Channels with the Borders of Cytoskeletal Cages Organizes the Secretory Machinery in Chromaffin Cells

The t-SNARE Complex: A Close Up

The Rho Guanine Nucleotide Exchange Factors Intersectin 1L and β-Pix Control Calcium-Regulated Exocytosis in Neuroendocrine PC12 Cells

Lipid Dynamics in Exocytosis

Polarized TIRFM Reveals Changes in Plasma Membrane Topology Before and During Granule Fusion

Dynamin and Myosin Regulate Differential Exocytosis from Mouse Adrenal Chromaffin Cells

Intravesicular Factors Controlling Exocytosis in Chromaffin Cells

Rapid Endocytosis and Vesicle Recycling in Neuroendocrine Cells

Commentary on Chapters ‘Clinical and Developmental Aspects’ and ‘Stress Responses of the Adrenal Medulla’

Carboxypeptidase E: Elevated Expression Correlated with Tumor Growth and Metastasis in Pheochromocytomas and Other Cancers

Expression of Trophic Peptides and Their Receptors in Chromaffin Cells and Pheochromocytoma

Human Tyrosine Hydroxylase Natural Allelic Variation: Influence on Autonomic Function and Hypertension

Naturally Occurring Genetic Variants in Human Chromogranin A (CHGA) Associated with Hypertension as well as Hypertensive Renal Disease

The Coffin-Lowry Syndrome-Associated Protein rsk2 and Neurosecretion

Past, Present and Future of Human Chromaffin Cells: Role in Physiology and Therapeutics

Chromaffin Progenitor Cells from the Adrenal Medulla

Developmental and Stress-Induced Remodeling of Cell–Cell Communication in the Adrenal Medullary Tissue

Adrenal Responses to Stress

Neuropeptides, Growth Factors, and Cytokines: A Cohort of Informational Molecules Whose Expression Is Up-Regulated by the Stress-Associated Slow Transmitter PACAP in Chromaffin Cells

Stress and Adrenergic Function: HIF1α, a Potential Regulatory Switch

Vesicular Monoamine Transporters (VMATs) in Adrenal Chromaffin Cells: Stress-Triggered Induction of VMAT2 and Expression in Epinephrine Synthesizing Cells

Cytokine Interactions with Adrenal Medullary Chromaffin Cells

Cellular and Molecular Neurobiology : Volume 30, Issue 7, October 2010

Cellular and Molecular Neurobiology : Volume 30, Issue 6, August 2010

Cellular and Molecular Neurobiology : Volume 30, Issue 5, July 2010

Cellular and Molecular Neurobiology : Volume 30, Issue 4, May 2010

Cellular and Molecular Neurobiology : Volume 30, Issue 3, April 2010

Cellular and Molecular Neurobiology : Volume 30, Issue 2, March 2010

Cellular and Molecular Neurobiology : Volume 30, Issue 1, January 2010

Cellular and Molecular Neurobiology : Volume 29

Cellular and Molecular Neurobiology : Volume 28

Cellular and Molecular Neurobiology : Volume 27

Cellular and Molecular Neurobiology : Volume 26

Cellular and Molecular Neurobiology : Volume 25

Cellular and Molecular Neurobiology : Volume 24

Cellular and Molecular Neurobiology : Volume 23

Cellular and Molecular Neurobiology : Volume 22

Cellular and Molecular Neurobiology : Volume 21

Cellular and Molecular Neurobiology : Volume 20

Cellular and Molecular Neurobiology : Volume 19

Cellular and Molecular Neurobiology : Volume 18

Cellular and Molecular Neurobiology : Volume 17

The Coffin-Lowry Syndrome-Associated Protein rsk2 and Neurosecretion

Content Provider	Springer Nature Link
Author	Zeniou Meyer, M. Gambi, F. Ammar, Mohamed Raafet Humeau, Y. Vitale, N.
Copyright Year	2010
Abstract	Coffin-Lowry syndrome (CLS) is a syndromic form of X-linked mental retardation, characterized in male patients by psychomotor and growth retardation and various skeletal anomalies. CLS is caused by mutations in the RPS6KA3 gene, which encodes RSK2, a growth factor-regulated protein kinase. Cognitive deficiencies in CLS patients are prominent, but markedly variable in severity, even between siblings. However, the vast majority of patients are severely affected, with mental retardation ranging from moderate to profound. We used a RSK2-KO mouse model that shows no obvious brain abnormalities at the anatomical and histological levels to study the function of RSK2 in neurosecretion. Behavioral studies revealed normal motor coordination, but a profound retardation in spatial learning and a deficit in long-term spatial memory, providing evidence that RSK2 plays similar roles in mental functioning both in mice and human. We found that associative LTP at cortical inputs to the lateral amygdala was blocked in Rsk2 KO mice. Using an RNA interference rescue strategy in PC12 cells, we were able to demonstrate that RSK2 regulates catecholamine release through the phosphorylation of PLD. These results provide the first molecular evidence that RSK2 could regulate neurotransmitter release by activating PLD production of lipids required for exocytosis.
Starting Page	1401
Ending Page	1406
Page Count	6
File Format	PDF
ISSN	02724340
Journal	Cellular and Molecular Neurobiology
Volume Number	30
Issue Number	8
e-ISSN	15736830
Language	English
Publisher	Springer US
Publisher Date	2010-11-09
Publisher Place	Boston
Access Restriction	Subscribed
Subject Keyword	RSK2 Exocytosis PLD Mental retardation Coffin-Lowry syndrome Neurobiology Cell Biology Neurosciences
Content Type	Text
Resource Type	Article
Subject	Cell Biology Medicine Cellular and Molecular Neuroscience

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Altered neurodevelopment associated with mutations of RSK2: a morphometric MRI study of Coffin–Lowry syndrome

Mutations in the RSK2(RPS6KA3) gene cause Coffin-Lowry syndrome and nonsyndromic X-linked mental retardation

Unraveling molecular, cellular and cognitive defects in the mouse model for mental retardation caused by Rsk2 gene mutation

Animal Models for Coffin-Lowry Syndrome: RSK2 and Nervous System Dysfunction

The Coffin–Lowry syndrome-associated protein RSK2 is implicated in calcium-regulated exocytosis through the regulation of PLD1

The Coffin-Lowry syndrome-associated protein RSK2 regulates neurite outgrowth through phosphorylation of phospholipase D1 (PLD1) and synthesis of phosphatidic acid

Coffin-Lowry Syndrome: The First Molecularly Confirmed Report in Iran

Growth Concerns in Coffin–Lowry Syndrome: A Case Report and Literature Review

Deletion of the Coffin–Lowry Syndrome Gene Rsk2 in Mice is Associated With Impaired Spatial Learning and Reduced Control of Exploratory Behavior

The Coffin-Lowry Syndrome-Associated Protein rsk2 and Neurosecretion

Similar Documents

Altered neurodevelopment associated with mutations of RSK2: a morphometric MRI study of Coffin–Lowry syndrome

Mutations in the RSK2(RPS6KA3) gene cause Coffin-Lowry syndrome and nonsyndromic X-linked mental retardation

Unraveling molecular, cellular and cognitive defects in the mouse model for mental retardation caused by Rsk2 gene mutation

Animal Models for Coffin-Lowry Syndrome: RSK2 and Nervous System Dysfunction

The Coffin–Lowry syndrome-associated protein RSK2 is implicated in calcium-regulated exocytosis through the regulation of PLD1

The Coffin-Lowry syndrome-associated protein RSK2 regulates neurite outgrowth through phosphorylation of phospholipase D1 (PLD1) and synthesis of phosphatidic acid

Coffin-Lowry Syndrome: The First Molecularly Confirmed Report in Iran

Growth Concerns in Coffin–Lowry Syndrome: A Case Report and Literature Review

Deletion of the Coffin–Lowry Syndrome Gene Rsk2 in Mice is Associated With Impaired Spatial Learning and Reduced Control of Exploratory Behavior

The Coffin-Lowry Syndrome-Associated Protein rsk2 and Neurosecretion