NDLI: Expression of Trophic Peptides and Their Receptors in Chromaffin Cells and Pheochromocytoma

Content Provider	Springer Nature Link
Author	Thouёnn, Erwan Pierre, Alice Yon, Laurent Auar, Youssef
Copyright Year	2010
Abstract	Pheochromocytomas are catecholamine-producing tumors arising from chromaffin cells of the adrenal medulla or extra-adrenal location. Along with catecholamines, tumoral cells produce and secrete elevated quantities of trophic peptides which are normally released in a regulated manner by the normal adrenal medulla. Among these peptides, the amounts of pituitary adenylate cyclase-activating polypeptide (PACAP), adrenomedullin (AM), and neuropeptide Y (NPY) are particularly high. These peptides can exert endocrine, paracrine or autocrine effects in numerous cell types. In particular, they have been shown to be involved in cell proliferation and survival, catecholamine production and secretion, and angiogenesis. Some of these processes are exacerbated in pheochromocytomas, raising the possibility of the involvement of trophic peptides. Here, we review the expression levels of NPY, PACAP, and AM and theirs receptors in chromaffin cells and pheochromocytomas, and address their possible implication in the adrenal medulla tumorigenesis and malignant development of pheochromocytomas.
Starting Page	1383
Ending Page	1389
Page Count	7
File Format	PDF
ISSN	02724340
Journal	Cellular and Molecular Neurobiology
Volume Number	30
Issue Number	8
e-ISSN	15736830
Language	English
Publisher	Springer US
Publisher Date	2010-11-03
Publisher Place	Boston
Access Restriction	Subscribed
Subject Keyword	Chromaffin cells Pheochromocytomas Trophic peptides Tumorigenesis Malignancy Neurobiology Cell Biology Neurosciences
Content Type	Text
Resource Type	Article
Subject	Cell Biology Medicine Cellular and Molecular Neuroscience

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