NDLI: Retinol, vitamins A, C, and E and breast cancer risk: a meta-analysis and meta-regression

Content Provider	Springer Nature Link
Author	Fulan, Hu Changxing, Jiang Baina, Wang Yi Wencui, Zhang Chunqing, Lin Fan, Wang Dandan, Li Dianjun, Sun Tong, Wang Da, Pang Yashuang, Zhao
Copyright Year	2011
Abstract	To comprehensively summarize the associations between retinol, vitamins A, C, and E and breast cancer, and quantitatively estimate their dose–response relationships.We searched PubMed, Embase, and Cochrane databases (from January 1982 to 15 March 2011) and the references of the relevant articles in English with sufficient information to estimate relative risk or odds ratio and the 95% confidence intervals, and comparable categories of vitamins. Two reviewers independently extracted data using a standardized form, with any discrepancy adjudicated by the third reviewer.Overall, 51 studies met the inclusion criteria. Comparing the highest with the lowest intake, total vitamin A intake reduced the breast cancer risk by 17% (pooled OR = 0.83, 95% CI: 0.78–0.88). Further subgroup analysis based on study design did not change the significant reduction. Although the dietary vitamin A, dietary vitamin E, and total vitamin E intake all reduced breast cancer risk significantly when data from all studies were pooled, the results became nonsignificant when data from cohort studies were pooled. The significant association between total retinol intake and breast cancer in all studies became nonsignificant in case–control studies but remain significant in cohort studies. No significant dose–response relationship was observed in the higher intake of these vitamins with reduced breast cancer risk.Our results indicate that both the total intake of vitamin A and retinol could reduce breast cancer risk. However, associations between other vitamins and breast cancer seem to be limited.
Starting Page	1383
Ending Page	1396
Page Count	14
File Format	PDF
ISSN	09575243
Journal	Cancer Causes & Control
Volume Number	22
Issue Number	10
e-ISSN	15737225
Language	English
Publisher	Springer Netherlands
Publisher Date	2011-07-15
Publisher Place	Dordrecht
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Retinol Vitamin A Vitamin C Vitamin E Breast cancer Meta-analysis Epidemiology Oncology Cancer Research Public Health/Gesundheitswesen Biomedicine general Hematology
Content Type	Text
Resource Type	Article
Subject	Cancer Research Oncology

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