NDLI: The association between height and prostate cancer grade in the Early Stage Prostate Cancer Cohort Study

Content Provider	Springer Nature Link
Author	Farwell, Wildon R. Lourenco, Christopher Holmberg, Erika Hall, Robert B. D’Avolio, Leonard Lawler, Elizabeth V. Michael Gazia, J.
Copyright Year	2011
Abstract	We examined the relationship between height and prostate cancer grade.The Early Stage Prostate Cancer Cohort Study is an observational cohort of 1,037 men diagnosed with early-stage prostate cancer, T0–3NxM0. High-grade prostate cancer was defined as a biopsy Gleason score ≥ 7 (4 + 3). Logistic regression models were created to calculate odds ratios (OR) and 95% confidence intervals (CI) for the cross-sectional relationship between height and prostate cancer grade in the overall cohort and subpopulations.We identified 939 participants with a biopsy Gleason score. High-grade prostate cancer was diagnosed in 138 participants. Overall, participants in the highest quartile of height were more than twice as likely to have a Gleason score ≥ 7 (4 + 3) than participants in the lowest quartile of height, OR 2.14 (95% CI 1.11, 4.14), after multivariate adjustment. Participants in the highest quartile of height were more likely to be diagnosed with high-grade prostate cancer than participants in the lowest quartile of height among participants who were black, OR 8.00 (95% CI 1.99, 32.18), and participants who had diabetes mellitus, OR 5.09 (95% CI 1.30, 19.98).Height is associated with increased risk of high-grade prostate cancer overall and perhaps among certain subpopulations.
Starting Page	1453
Ending Page	1459
Page Count	7
File Format	PDF
ISSN	09575243
Journal	Cancer Causes & Control
Volume Number	22
Issue Number	10
e-ISSN	15737225
Language	English
Publisher	Springer Netherlands
Publisher Date	2011-07-20
Publisher Place	Dordrecht
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Prostatic neoplasms Body height Epidemiology Oncology Cancer Research Public Health/Gesundheitswesen Biomedicine general Hematology
Content Type	Text
Resource Type	Article
Subject	Cancer Research Oncology

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1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
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