NDLI: The determinants of serum vitamin D levels in participants in a melanoma case–control study living in a temperate climate

Content Provider	Springer Nature Link
Author	Davies, John R. Chang, Yu Mei Swden, Helen Chan, May Leake, Susan Karpavicius, Birute Haynes, Sue Kukalizch, Kairen Randerson Moor, Juliette Elliott, Faye Barth, Julian Kanetsky, Peter A. Harland, Mark Bishop, D. Timothy Barrett, Jennifer H. Newton Bishop, Julia A.
Copyright Year	2011
Abstract	We report the determinants of serum levels of vitamin D in a UK melanoma case–control study benefitting from detailed exposure and genotyping data.Sun exposure, supplemental vitamin D, and SNPs reported to be associated with serum levels were assessed as predictors of a single serum 25-hydroxyvitamin D3 measurement adjusted for season, age, sex, and body mass index.Adjusted analyses showed that vitamin D levels were sub-optimal especially in the sun-sensitive individuals (−2.61 nmol/L, p = 0.03) and for inheritance of a genetic variant in the GC gene coding for the vitamin D-binding protein (−5.79 for heterozygotes versus wild type, p = <0.0001). Higher levels were associated with sun exposure at the weekend in summer (+4.71 nmol/L per tertile, p = <0.0001), and on hot holidays (+4.17 nmol/L per tertile, p = <0.0001). In smoothed scatter plots, vitamin D levels of 60 nmol/L in the non-sun-sensitive individuals were achieved after an average 6 h/day summer weekend sun exposure but not in the sun-sensitive individuals. Users of supplements had levels on average 11.0 nmol/L higher, p = <0.0001, and achieved optimal levels irrespective of sun exposure.Sun exposure was associated with increased vitamin D levels, but levels more than 60 nmol/L were reached on average only in individuals reporting lengthy exposure (≥12 h/weekend). The sun-sensitive individuals did not achieve optimal levels without supplementation, which therefore should be considered for the majority of populations living in a temperate climate and melanoma patients in particular. Inherited variation in genes such as GC is a strong factor, and carriers of variant alleles may therefore require higher levels of supplementation.
Starting Page	1471
Ending Page	1482
Page Count	12
File Format	PDF
ISSN	09575243
Journal	Cancer Causes & Control
Volume Number	22
Issue Number	10
e-ISSN	15737225
Language	English
Publisher	Springer Netherlands
Publisher Date	2011-08-19
Publisher Place	Dordrecht
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Vitamin D Sun exposure Vitamin D-binding protein NADSYN1 DHCR7 GC Sun sensitivity Supplementation Insufficiency CYP2R1 Epidemiology Oncology Cancer Research Public Health/Gesundheitswesen Biomedicine general Hematology
Content Type	Text
Resource Type	Article
Subject	Cancer Research Oncology

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The determinants of serum vitamin D levels in participants in a melanoma case–control study living in a temperate climate

The determinants of serum vitamin D levels in participants in a melanoma case–control study living in a temperate climate

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The determinants of serum vitamin D levels in participants in a melanoma case–control study living in a temperate climate

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The determinants of serum vitamin D levels in participants in a melanoma case–control study living in a temperate climate

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