NDLI: Risk of lung cancer in relation to contiguous windows of endotoxin exposure among female textile workers in Shanghai

Content Provider	Springer Nature Link
Author	Agalliu, Ilir Costello, Sadie Applebaum, Katie M. Ray, Roberta M. Astrakianakis, George Gao, Dao Li Thomas, David B. Checkoway, Harvey Eisen, Ellen A.
Copyright Year	2011
Abstract	Exposure to endotoxin has been consistently associated with a reduced risk of lung cancer. However, there is a paucity of information regarding temporal aspects of this relationship. The objective of this study was to investigate the associations between contiguous windows of endotoxin exposure and risk of lung cancer.Data were reanalyzed from a case-cohort study (602 cases, 3,038 subcohort) of female textile workers in Shanghai, China. Cumulative endotoxin exposure was partitioned into two windows: ≥20 and <20 years before risk. Exposure–response relations were examined using categorical and non-linear (semi-parametric) models, accounting for confounding by previous exposure windows.There was an inverse trend of decreasing risk of lung cancer associated with increasing levels of endotoxin exposure ≥20 years before risk (p trend = 0.02). Women in the highest two categories of cumulative exposures had hazard ratios of 0.78 (95% CI 0.60–1.03) and 0.77 (95% CI 0.58–1.02) for lung cancer, respectively, in comparison with unexposed textile workers. There was, however, a weaker association and not statistically significant between lung cancer and endotoxin exposure accumulated in the more recent window (<20 years before risk).Results provide further evidence that endotoxin exposure that occurred 20 years or more before risk confers the strongest protection against lung cancer, indicating a possible early anti-carcinogenic effect. Further studies are needed to better understand the underlying biological mechanisms for this effect.
Starting Page	1397
Ending Page	1404
Page Count	8
File Format	PDF
ISSN	09575243
Journal	Cancer Causes & Control
Volume Number	22
Issue Number	10
e-ISSN	15737225
Language	English
Publisher	Springer Netherlands
Publisher Date	2011-07-06
Publisher Place	Dordrecht
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Lung cancer Endotoxin Exposure windows Exposure–response models Latency Case-cohort analysis Non-parametric models Splines Epidemiology Oncology Cancer Research Public Health/Gesundheitswesen Biomedicine general Hematology
Content Type	Text
Resource Type	Article
Subject	Cancer Research Oncology

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Risk of lung cancer in relation to contiguous windows of endotoxin exposure among female textile workers in Shanghai

Reproductive factors and risk of lung cancer in female textile workers in Shanghai, China

Possible pro-carcinogenic association of endotoxin on lung cancer among Shanghai women textile workers.

Endotoxin exposure and lung cancer risk: a systematic review and meta-analysis of the published literature on agriculture and cotton textile workers

Colorectal Cancer Incidence Among Female Textile Workers in Shanghai, China: A Case-cohort Analysis of Occupational Exposures

Lung cancer mortality among European rock/slag wool workers: exposure-response analysis

A biological approach to characterizing exposure to metalworking fluids and risk of prostate cancer (United States)

Shift work and breast cancer among women textile workers in Shanghai, China

Lung Cancer Risk Among Female Textile Workers Exposed to Endotoxin

Risk of lung cancer in relation to contiguous windows of endotoxin exposure among female textile workers in Shanghai

Similar Documents

Risk of lung cancer in relation to contiguous windows of endotoxin exposure among female textile workers in Shanghai

Reproductive factors and risk of lung cancer in female textile workers in Shanghai, China

Possible pro-carcinogenic association of endotoxin on lung cancer among Shanghai women textile workers.

Endotoxin exposure and lung cancer risk: a systematic review and meta-analysis of the published literature on agriculture and cotton textile workers

Colorectal Cancer Incidence Among Female Textile Workers in Shanghai, China: A Case-cohort Analysis of Occupational Exposures

Lung cancer mortality among European rock/slag wool workers: exposure-response analysis

A biological approach to characterizing exposure to metalworking fluids and risk of prostate cancer (United States)

Shift work and breast cancer among women textile workers in Shanghai, China

Lung Cancer Risk Among Female Textile Workers Exposed to Endotoxin

Risk of lung cancer in relation to contiguous windows of endotoxin exposure among female textile workers in Shanghai