NDLI: Intake of vitamins A, C, and E and folate and the risk of ovarian cancer in a pooled analysis of 10 cohort studies

Content Provider	Springer Nature Link
Author	Koushik, Anita Wang, Molin Anderson, Kristin E. Brandt, Piet Clendenen, Tess V. Eliassen, A. Heather Freudenheim, Jo L. Genkinger, Jeanine M. Håkansson, Niclas Marshall, James R. McCullough, Marjorie L. Miller, Anthony B. Robien, Kim Rohan, Thomas E. Schairer, Catherine Schouten, Leo J. Tworoger, Shelley S. Wang, Ying Wolk, Alicja Zeleniuch Jacquotte, Anne Smith Warner, Stephanie A.
Copyright Year	2015
Abstract	Vitamins A, C, and E and folate have anticarcinogenic properties and thus might protect against cancer. Few known modifiable risk factors for ovarian cancer exist. We examined the associations between dietary and total (food and supplemental) vitamin intake and the risk of invasive epithelial ovarian cancer. The primary data from 10 prospective cohort studies in North America and Europe were analyzed. Vitamin intakes were estimated from validated food frequency questionnaires in each study. Study-specific relative risks (RRs) were estimated using the Cox proportional hazards model and then combined using a random-effects model.Among 501,857 women, 1,973 cases of ovarian cancer occurred over a median follow-up period of 7–16 years across studies. Dietary and total intakes of each vitamin were not significantly associated with ovarian cancer risk. The pooled multivariate RRs [95 % confidence intervals (CIs)] for incremental increases in total intake of each vitamin were 1.02 (0.97–1.07) for vitamin A (increment: 1,300 mcg/day), 1.01 (0.99–1.04) for vitamin C (400 mg/day), 1.02 (0.97–1.06) for vitamin E (130 mg/day), and 1.01 (0.96–1.07) for folate (250 mcg/day). Multivitamin use (vs. nonuse) was not associated with ovarian cancer risk (pooled multivariate RR = 1.00, 95 % CI 0.89–1.12). Associations did not vary substantially by study, or by subgroups of the population. Greater vitamin intakes were associated with modestly higher risks of endometrioid tumors (n = 156 cases), but not with other histological types.These results suggest that consumption of vitamins A, C, and E and folate during adulthood does not play a major role in ovarian cancer risk.
Starting Page	1315
Ending Page	1327
Page Count	13
File Format	PDF
ISSN	09575243
Journal	Cancer Causes & Control
Volume Number	26
Issue Number	9
e-ISSN	15737225
Language	English
Publisher	Springer International Publishing
Publisher Date	2015-07-14
Publisher Place	Cham
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Ovarian cancer Vitamin A Vitamin C Vitamin E Folate Pooled analysis Cohort studies Cancer Research Biomedicine general Oncology Public Health Epidemiology Hematology
Content Type	Text
Resource Type	Article
Subject	Cancer Research Oncology

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