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Possible pro-carcinogenic association of endotoxin on lung cancer among Shanghai women textile workers.
| Content Provider | Europe PMC |
|---|---|
| Author | Checkoway, H Lundin, J I Costello, S Ray, R Li, W Eisen, E A Astrakianakis, G Seixas, N Applebaum, K Gao, D L Thomas, D B |
| Copyright Year | 2014 |
| Abstract | Background:Endotoxin (lipopolysaccharide) is a widespread contaminant in many environmental settings. Since the 1970s, there has been generally consistent evidence indicating reduced risks for lung cancer associated with occupational endotoxin exposure.Methods:We updated a case–cohort study nested within a cohort of 267 400 female textile workers in Shanghai, China. We compared exposure histories of 1456 incident lung cancers cases diagnosed during 1989–2006 with those of a reference subcohort of 3022 workers who were free of lung cancer at the end of follow-up. We applied Cox proportional hazards modelling to estimate exposure–response trends, adjusted for age and smoking, for cumulative exposures lagged by 0, 10, and 20 years, and separately for time windows of ⩽15 and >15 years since first exposure.Results:We observed no associations between cumulative exposure and lung cancer, irrespective of lag interval. In contrast, analyses by exposure time windows revealed modestly elevated, but not statistically significant relative risks (∼1.27) at the highest three exposure quintiles for exposures that occurred >15 years since first exposure.Conclusions:The findings do not support a protective effect of endotoxin, but are suggestive of possible lung cancer promotion with increasing time since first exposure. |
| ISSN | 00070920 |
| Journal | British Journal of Cancer |
| Volume Number | 111 |
| PubMed Central reference number | PMC4119981 |
| Issue Number | 3 |
| PubMed reference number | 24921918 |
| e-ISSN | 15321827 |
| DOI | 10.1038/bjc.2014.308 |
| Language | English |
| Publisher | Nature Publishing Group |
| Publisher Date | 2014-06-12 |
| Access Restriction | Open |
| Rights License | From twelve months after its original publication, this work is licensed under the Creative Commons Attribution-NonCommercial-Share Alike 3.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-sa/3.0/ Copyright © 2014 Cancer Research UK |
| Subject Keyword | endotoxin lipopolysaccharide lung cancer epidemiology textile industry occupational health |
| Content Type | Text |
| Resource Type | Article |
| Subject | Cancer Research Oncology |
