NDLI: Chaotic fluid mixing by alternating microparticle topologies to enhance biochemical reactions

Content Provider	Springer Nature Link
Author	Gao, Y. Reenen, A. Hulsen, M. A. Jong, A. M. Prins, M. W. J. Toonder, J. M. J.
Copyright Year	2013
Abstract	We report experimental results on chaotic mass transport induced by alternating topological changes of magnetic particle chains actuated by a rotating magnetic field. Results on the induced fluid flows, through particle tracing experiments and mixing experiments, are obtained for (1) the regime of rigid chain rotation and (2) the regime wherein chains periodically fragment and reform. In the case of rigid rotating chains, the overall tracer particle trajectories are steady, slightly modulated circles around the center of the microparticle chains. In the regime of periodic chain breaking and reformation, the tracer particle trajectories become chaotic. The level of mixing is measured by using a mixing index (M) in a water–dye system, i.e., in a perfectly mixed system M = 0, while in an unmixed system M = 1. When particle chains periodically break and reform, we observe that the mixing index M decreases from 1 to 0.1 within 15 rotational cycles. For rigid rotating chains, M reaches a minimum of only 0.5. We also report the effect of the different actuation regimes on a biological binding reaction in the solution and indeed found that the reaction product (at equal actuation time) is significantly enhanced (3 times) by the dynamic chain regime as compared to the rigid chain regime. We conclude that the alternating topological change of microparticle chains—with repetitive chain breakup and chain reformation—is an effective mechanism to achieve chaotic mixing and thereby promote and homogenize reactions in lab-on-a-chip systems.
Starting Page	265
Ending Page	274
Page Count	10
File Format	PDF
ISSN	16134982
Journal	Microfluidics and Nanofluidics
Volume Number	16
Issue Number	1-2
e-ISSN	16134990
Language	English
Publisher	Springer Berlin Heidelberg
Publisher Date	2013-06-07
Publisher Place	Berlin, Heidelberg
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Microfluidic flow Microfluidic mixing Magnetic particles Particle dynamics Affinity assay Engineering Fluid Dynamics Biomedical Engineering Analytical Chemistry Nanotechnology and Microengineering
Content Type	Text
Resource Type	Article
Subject	Nanoscience and Nanotechnology Materials Chemistry Condensed Matter Physics Electronic, Optical and Magnetic Materials

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4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
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