NDLI: Microfluidic mixing using pulsating flows

Content Provider	Springer Nature Link
Author	Cheaib, Farah Kekejian, Gacia Antoun, Sylvie Cheikh, Mohammad Lakkis, Issam
Copyright Year	2016
Abstract	Mixing of biological species in microfluidic channels is challenging since the mixing process is limited by the small mass diffusion coefficient of the species and by the dominance of viscous effects, captured by the low value of Reynolds number characteristic of laminar liquid flow in microchannels. This paper investigates the use of pulsating flows to enhance mixing in microflows. The dependence of the degree of mixing on various dimensionless groups is investigated. These dimensionless numbers are Strouhal number, pulse amplitude divided by base velocity, Reynolds number, location along the mixing channel normalized by the channel width, channel cross section aspect ratio, and phase difference between the inlet streams. The degree of mixing, observed to experience both spatial fluctuations down the mixing channel and temporal fluctuations over a pulsation cycle at the quasi-stationary state, is shown to be most sensitive to changes in pulsation amplitude and frequency. For a fixed pulsation amplitude and Reynolds number, the degree of mixing has a peak value for a certain Strouhal number above and below which the degree of mixing decreases. Increasing the pulsation amplitude improves mixing with the behavior becoming asymptotic at large pulsation amplitudes. The temporal fluctuations in the degree of mixing over a cycle at the quasi-stationary state decrease and the average degree of mixing increases downstream the mixing channel. The fluctuations are also smaller at higher values of the Strouhal number and are generally larger for larger pulsation amplitudes. This study also takes into account the rate of work input required to overcome viscous effects. While this power input is independent of the pulsation frequency, it exhibits a parabolic dependence on the pulsation amplitude. Finally, considering the dependence of the degree of mixing (mean and standard deviation), mixing length, and energy consumption on these dimensionless groups, examples of the trade-off that has to be made in choosing the operating conditions based on different constraints are presented.
Starting Page	1
Ending Page	19
Page Count	19
File Format	PDF
ISSN	16134982
Journal	Microfluidics and Nanofluidics
Volume Number	20
Issue Number	5
e-ISSN	16134990
Language	English
Publisher	Springer Berlin Heidelberg
Publisher Date	2016-04-16
Publisher Place	Berlin, Heidelberg
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Microfluidic mixing Pulsating flows More Engineering Fluid Dynamics Biomedical Engineering Analytical Chemistry Nanotechnology and Microengineering
Content Type	Text
Resource Type	Article
Subject	Nanoscience and Nanotechnology Materials Chemistry Condensed Matter Physics Electronic, Optical and Magnetic Materials

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Mapping low-Reynolds-number microcavity flows using microfluidic screening devices

Spindle-shaped microfluidic chamber with uniform perfusion flows

Chaotic fluid mixing by alternating microparticle topologies to enhance biochemical reactions

Mixing in an enclosed microfluidic chamber through moving boundary motions

Rapid microfluidic mixer utilizing sharp corner structures

Orbiting magnetic microbeads enable rapid microfluidic mixing

Quantitative analysis of microfluidic mixing using microscale schlieren technique

Micromixing by pneumatic agitation on continually rotating centrifugal microfluidic platforms

Imaging liquids using microfluidic cells

Microfluidic mixing using pulsating flows

Similar Documents

Mapping low-Reynolds-number microcavity flows using microfluidic screening devices

Spindle-shaped microfluidic chamber with uniform perfusion flows

Chaotic fluid mixing by alternating microparticle topologies to enhance biochemical reactions

Mixing in an enclosed microfluidic chamber through moving boundary motions

Rapid microfluidic mixer utilizing sharp corner structures

Orbiting magnetic microbeads enable rapid microfluidic mixing

Quantitative analysis of microfluidic mixing using microscale schlieren technique

Micromixing by pneumatic agitation on continually rotating centrifugal microfluidic platforms

Imaging liquids using microfluidic cells

Microfluidic mixing using pulsating flows