NDLI: Plastic LC/MS microchip with an embedded microstructured fibre having the dual role of a frit and a nanoelectrospray emitter

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Plastic LC/MS microchip with an embedded microstructured fibre having the dual role of a frit and a nanoelectrospray emitter

Content Provider	Springer Nature Link
Author	Mats, Lili Gibson, Graham T. T. Oleschuk, Richard D.
Copyright Year	2013
Abstract	Integrating functionality on a microfluidic platform, such as a frit or electrospray emitter for coupling with a mass spectrometer, can be complicated, costly, and introduce dead volume deleterious to liquid chromatography (LC). Here, we demonstrate the fabrication of a LC/MS microchip device with an integrated nanoelectrospray emitter that also functions as a retaining frit. The integrated emitter effectively minimizes dead volume associated with coupling the device externally to MS with electrospray ionization and complications associated with frit microfabrication. The emitter is made of microstructured optical fibre, which has an array of equivalent parallel channels. The size and spacing of these channels make the fibre amenable to retaining chromatographic packing material while simultaneously performing as a nanoelectrospray emitter. The chromatographic chip is fashioned from cyclic olefin copolymer (Zeonor) using hot embossing and thermal/solvent bonding techniques. The device is fabricated in less than 3 h with simple technique and low-cost materials while maintaining sufficient solvent resistance and mechanical strength, withstanding pressure drops of up to 100 bar. This microchip was used to effectively separate small drug molecules by isocratic elution and larger peptides using gradient elution. Robustness of the plastic LC/MS devices was demonstrated by frequent use over several months with consistent results. Such devices represent a practical approach to the facile integration of a frit and/or an ESI emitter in a microfluidic device at low cost while minimizing dead volume associated with coupling the chip to MS.
Starting Page	73
Ending Page	81
Page Count	9
File Format	PDF
ISSN	16134982
Journal	Microfluidics and Nanofluidics
Volume Number	16
Issue Number	1-2
e-ISSN	16134990
Language	English
Publisher	Springer Berlin Heidelberg
Publisher Date	2013-07-04
Publisher Place	Berlin, Heidelberg
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Polymer microchip Liquid chromatography–mass spectrometry Cyclic olefin copolymer Microstructured fibre Hot embossing Engineering Fluid Dynamics Biomedical Engineering Analytical Chemistry Nanotechnology and Microengineering
Content Type	Text
Resource Type	Article
Subject	Nanoscience and Nanotechnology Materials Chemistry Condensed Matter Physics Electronic, Optical and Magnetic Materials

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1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
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