NDLI: Microfabrication of high temperature micro-reactors for continuous flow isotope ratio mass spectrometry

Please wait, while we are loading the content...

Selectively modified microfluidic chip for solvent extraction of Radix Salvia Miltiorrhiza using three-phase laminar flow to provide double liquid–liquid interface area

Effects of fibrous matrix on flow startup and control in parallel PDMS microchannels with a common inlet

A dynamic piezoelectric micropumping phenomenon

Capillary contributions to the dynamics of discrete slugs in microchannels

Dielectrophoretic-activated cell sorter based on curved microelectrodes

A microfluidic cross-flowing emulsion generator for producing biphasic droplets and anisotropically shaped polymer particles

Simplified and direct microchannels fabrication at wafer scale with negative and positive photopolymerizable polydimethylsiloxanes

Detecting molecular separation in nano-fluidic channels through velocity analysis of temporal image sequences by multivariate curve resolution

Microfabrication of high temperature micro-reactors for continuous flow isotope ratio mass spectrometry

Rarefied gas flow of binary mixtures through long channels with triangular and trapezoidal cross sections

Three-dimensional microfluidic chip for the extraction of mitochondrial DNA

Flow past superhydrophobic surfaces containing longitudinal grooves: effects of interface curvature

Gaseous slip flow of a rectangular microchannel with non-uniform slip boundary conditions

A novel splitter design for microfluidic biochips using centrifugal driving forces

A rapid and simple fabrication method for 3-dimensional circular microfluidic channel using metal wire removal process

Pneumatic pumping in centrifugal microfluidic platforms

Hydrodynamically driven docking of blocks for 3D fluidic assembly

Pressure sensor positioning in an electrokinetic microrheometer device: simulations of shear-thinning liquid flows

Dramatic squat and trim phenomena of mm-scaled SU-8 boats induced by Marangoni effect

Three-dimensional non-linear AC electro-osmotic flow induced by a face-to-face, asymmetric pair of planar electrodes

A lab-on-a-chip capillary network for red blood cell hydrodynamics

Microfluidics and Nanofluidics : Volume 9, Issue 1, July 2010

Microfluidics and Nanofluidics : Volume 8

Microfluidics and Nanofluidics : Volume 7

Microfluidics and Nanofluidics : Volume 6

Microfluidics and Nanofluidics : Volume 5

Microfluidics and Nanofluidics : Volume 4

Microfluidics and Nanofluidics : Volume 3

Microfluidics and Nanofluidics : Volume 2

Microfluidics and Nanofluidics : Volume 1

Microfabrication of high temperature micro-reactors for continuous flow isotope ratio mass spectrometry

Content Provider	Springer Nature Link
Author	Tobias, Herbert J. Brenna, J. Thomas
Copyright Year	2010
Abstract	Robust, high temperature micro-reactors for on-line conversion of organic compounds were microfabricated in high purity fused silica to enable stable isotopic compositional analysis of individual compounds in mixtures using advanced gas chromatography (GC) separation techniques, such as fast GC and comprehensive 2D GC, coupled to isotope ratio mass spectrometry (IRMS). These micro-reactors could also be manufactured at larger channel dimensions to enable robust operations for normal GCC-IRMS applications. Photolithography was used to define the reactor channel pattern on high purity fused silica, with a protective layer of amorphous silicon. A two-step isotropic wet etching process, using 49% HF, selectively created semi-circular cross-section micro-channels of arbitrary diameters (56–209 μm), with tapered sections leading to input/output ports (>400 μm) that accept fused silica capillary tubing used in GC and MS peripherals. Pairs of symmetric mirror image substrates were aligned and bonded to form enclosed circular channels. The resulting micro-reactors are more robust than the standard designs made of fragile-fused silica capillary or alumina tubes of relatively large bore, and are gas tight at temperatures up to 1,000°C. Fast GC plugs of CH4 with and without the reactor revealed that peak shapes are minimally affected by the micro-reactor when carrier flow rate and channel diameter are optimized. Peak shapes with full widths at half maximum of 250 ms are shown for plugs of CH4 through a fast-GC-combustion-IRMS system interfaced with a micro-reactor containing a CuO/NiO combustion source, enabling carbon isotope ratio measurements of CH4 with a precision of SD(δ13C) = ±0.28‰. The devices enable arbitrarily narrow bores and long path channels that can be operated as open tubes or loaded with a reactant, in a small, robust package.
Starting Page	461
Ending Page	470
Page Count	10
File Format	PDF
ISSN	16134982
Journal	Microfluidics and Nanofluidics
Volume Number	9
Issue Number	2-3
e-ISSN	16134990
Language	English
Publisher	Springer-Verlag
Publisher Date	2010-01-28
Publisher Place	Berlin, Heidelberg
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	High purity fused silica Micro-reactor High temperature Gas chromatography Combustion Isotope ratio mass spectrometry Biomedical Engineering Engineering Fluid Dynamics
Content Type	Text
Resource Type	Article
Subject	Nanoscience and Nanotechnology Materials Chemistry Condensed Matter Physics Electronic, Optical and Magnetic Materials

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Nanoparticle synthesis completed with in situ catalyst preparation performed on a high-pressure high-temperature continuous flow reactor

Gas–liquid dynamics at low Reynolds numbers in pillared rectangular micro channels

Microfabrication-free fused silica nanofluidic interface for on chip electrokinetic stacking of DNA

An online method to determine chlorine stable isotope composition by continuous flow isotope ratio mass spectrometry (CF-IRMS) coupled with a Gasbench II

Study of High Aspect Ratio NLD Plasma Etching and Postprocessing of Fused Silica and Borosilicate Glass

Deuterated isotope labelling of phenol derivatives within micro reactors

Temperature distribution effects on micro-CFPCR performance

High throughput screening of organic residues in archaeological potsherds using direct acidified methanol extraction

Comparison of high-temperature conversion and equilibration methods for the determination of d31-palmitic acid oxidation in man using continuous-flow isotope ratio mass spectrometry

Microfabrication of high temperature micro-reactors for continuous flow isotope ratio mass spectrometry

Similar Documents

Nanoparticle synthesis completed with in situ catalyst preparation performed on a high-pressure high-temperature continuous flow reactor

Gas–liquid dynamics at low Reynolds numbers in pillared rectangular micro channels

Microfabrication-free fused silica nanofluidic interface for on chip electrokinetic stacking of DNA

An online method to determine chlorine stable isotope composition by continuous flow isotope ratio mass spectrometry (CF-IRMS) coupled with a Gasbench II

Study of High Aspect Ratio NLD Plasma Etching and Postprocessing of Fused Silica and Borosilicate Glass

Deuterated isotope labelling of phenol derivatives within micro reactors

Temperature distribution effects on micro-CFPCR performance

High throughput screening of organic residues in archaeological potsherds using direct acidified methanol extraction

Comparison of high-temperature conversion and equilibration methods for the determination of d31-palmitic acid oxidation in man using continuous-flow isotope ratio mass spectrometry

Microfabrication of high temperature micro-reactors for continuous flow isotope ratio mass spectrometry