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| Content Provider | Springer Nature Link |
|---|---|
| Author | Szafarz, Malgorzata Szymura Oleksiak, Joanna Lazewska, Dorota Kiec Kowicz, Katarzyna |
| Copyright Year | 2011 |
| Abstract | A sensitive and specific liquid chromatography electrospray ionisation–tandem mass spectrometry method for determination of new non-imidazole histamine H3 receptor antagonist 1-[3-(4-tert-butylphenoxy)propyl]piperidine (DL76) in rat serum has been developed and validated. Chromatography was performed on a XBridge™ C18 analytical column (2.1 × 30 mm, 3.5 µm, Waters, Ireland) with gradient elution using a mobile phase containing acetonitrile and water with an addition of 0.1% of formic acid. Detection was achieved by an Applied Biosystems MDS Sciex (Concord, Ontario, Canada) API 2000 triple quadrupole mass spectrometer. Electrospray ionization (ESI) was used for ion production. The limit of detection in the SRM mode was found to be 0.5 ng mL−1. The limit of quantification was 1 ng mL−1. The precision and accuracy for both intra- and inter-day determination of DL76 ranged from 1.65 to 15.09% and from 88.74 to 113.43%. The results of this analytical method validation allow to carry out pharmacokinetic studies in rats. The method was used for the pilot study of the pharmacokinetic behavior of DL76 in rats after intravenous administration. |
| Starting Page | 913 |
| Ending Page | 919 |
| Page Count | 7 |
| File Format | |
| ISSN | 00095893 |
| Journal | Chromatographia |
| Volume Number | 73 |
| Issue Number | 9-10 |
| e-ISSN | 16121112 |
| Language | English |
| Publisher | Springer-Verlag |
| Publisher Date | 2011-02-25 |
| Publisher Place | Berlin, Heidelberg |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Column liquid chromatography Tandem MS detection DL76 compound Histamine H3 receptor antagonist Rats serum Plant Sciences Pharmacy Organic Chemistry Proteomics Biochemistry Analytical Chemistry |
| Content Type | Text |
| Resource Type | Article |
| Subject | Organic Chemistry Analytical Chemistry Biochemistry Clinical Biochemistry |
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