NDLI: Three-Phase Solvent Bar Microextraction Combined with HPLC for Extraction and Determination of Plasma Protein Binding of Bisoprolol

Content Provider	Springer Nature Link
Author	Zhang, Ming Li, Qing Ji, Wei Jiang, Shan Ma, Chao Wang, Chao Ye, Jing Cui, Yan Liu, Wentao Bi, Kaishun Chen, Xiaohui
Copyright Year	2011
Abstract	A three-phase solvent bar microextraction (TPSBME) technique combined with high performance liquid chromatography (HPLC)–fluorescence detection was evaluated for the quantitative determination of plasma protein binding of bisoprolol. Bisoprolol was extracted from a 5.6-mL basified plasma sample (donor phase) into the organic solvent (n-octanol) impregnated in the pores of a hollow fiber and then extracted into an acidic solution (acceptor phase) inside the lumen of the hollow fiber. Metoprolol was used as the internal standard. Several parameters influencing the efficiency of the method were investigated and optimized including organic solvent (n-butanol, n-octanol, dibutyl phthalate, dihexyl ether), stirring rate (100–1,000 rpm), extraction time (5–35 min), extraction temperature (15–45 °C), concentration of the donor phase (0.1–2 M NaOH) and the acceptor phase (0.5–5 M formic acid), salt concentration (2.5–10%, w/v). Under the optimal condition, extraction recoveries from plasma samples were above 61.4% for bisoprolol. The calibration curves were obtained in the range of 10–100 ng mL−1 with reasonable linearity (r > 0.994). The method was successfully applied to determine the plasma protein binding rate of bisoprolol.
Starting Page	897
Ending Page	903
Page Count	7
File Format	PDF
ISSN	00095893
Journal	Chromatographia
Volume Number	73
Issue Number	9-10
e-ISSN	16121112
Language	English
Publisher	Springer-Verlag
Publisher Date	2011-03-03
Publisher Place	Berlin, Heidelberg
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Solvent bar microextraction Bisoprolol HPLC Plasma Plant Sciences Pharmacy Organic Chemistry Proteomics Biochemistry Analytical Chemistry
Content Type	Text
Resource Type	Article
Subject	Organic Chemistry Analytical Chemistry Biochemistry Clinical Biochemistry

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