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Evidence for non-random distribution of Fcγ receptor genotype combinations

Content Provider	Springer Nature Link
Author	Pol, W. Ludo Jansen, Marc D. Sluiter, Wim J. Sluis, Bart Leppers van de Straat, Fredriek G. J. Kobayashi, Tetsuo Westendorp, Rudi G. J. Huizinga, Tom W. J. Winkel, Jan G. J.
Copyright Year	2003
Abstract	Human IgG receptors (FcγR) display considerable heterogeneity, and are crucial immune response modulating molecules. FcγRIIA, FcγRIIIA, and FcγRIIIB display functional biallelic polymorphisms. FcγR polymorphisms have been found associated with susceptibility to infectious and autoimmune diseases. Linked transmission of FcγR alleles was studied by determining the distribution of FcγRIIA-FcγRIIIA-FcγRIIIB genotype combinations in 514 Dutch Caucasian, and 149 Japanese blood donors. The structure of the FcγR locus was studied by radiation hybrid mapping of FcγRIA, FcγRIIA, FcγRIIB, FcγRIIIA, FcγRIIIB, and adjacent genes from the pentraxin family. In addition, crossing-over frequencies within the FcγR locus were determined in 63 Dutch Caucasian families, encompassing 183 individuals. FcγRII and FcγRIII subclasses were mapped in close proximity (0.47–3.14 cR). Accordingly, crossing-over frequencies within the FcγRII-III locus in Dutch families were low. Analysis of combined FcγR genotypes strongly suggested non-random distribution of FcγRIIA-FcγRIIIA-, and FcγRIIIA-FcγRIIIB genotypes in Dutch donors (P<0.001 and P<0.00001, respectively), and of FcγRIIA-FcγRIIIb genotypes in Japanese blood donors (P<0.02). Frequencies of FcγRII-FcγRIII haplotypes differed significantly between Dutch and Japanese (P<0.00001). This study provides important information for the interpretation of studies reporting associations of FcγR alleles with disease, and underscores the apparent differences in FcγR heterogeneity between ethnic groups.
Starting Page	240
Ending Page	246
Page Count	7
File Format	PDF
ISSN	00937711
Journal	Immunogenetics
Volume Number	55
Issue Number	4
e-ISSN	14321211
Language	English
Publisher	Springer-Verlag
Publisher Date	2003-06-26
Publisher Place	Berlin, Heidelberg
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Fcγ receptors Human Polymorphism
Content Type	Text
Resource Type	Article
Subject	Genetics Immunology

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