NDLI: VNTR polymorphism of human IL1RN in Chinese Han and She ethnic populations.

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VNTR polymorphism of human IL1RN in Chinese Han and She ethnic populations.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Xu, D-P Ruan, Y-Y Pan, Y-Q Lin, A. Li, M. Yan, W-H
Spatial Coverage	China
Description	Country affiliation: China Author Affiliation: Xu DP ( Medical Research Center, Taizhou Hospital of Zhejiang Province, Wenzhou Medical College, Linhai, Zhejiang, China.)
Abstract	Interleukin 1 receptor antagonist (IL-1Ra) is an important anti-inflammatory molecule encoded by the IL1RN gene. The polymorphism of IL1RN characterized by variable numbers of an 86 bp tandem repeat (VNTR) sequence in intron 2 has been described. Moreover, frequencies of the IL1RN alleles vary among different ethnics. In the present study, we analysed the IL1RN polymorphism in intron 2 in 256 Chinese Han and 252 Chinese She individuals. Four alleles including IL1RN1, 2, 3 and IL1RN4 were identified in this study. Data revealed that the distribution of the IL-1RN genotypes and allele was significantly different between the two Chinese populations (P < 0.001). Among them, 66.8% (171/256) and 86.5% (218/252) were homozygous for the allele IL-1RN1 in Chinese Han and She individuals respectively. Homozygosity for allele IL-1RN2 was only observed in Chinese Han with the percentage of 0.8% (2/256). Heterozygosity for IL-1RN1/2, IL1RN1/3 and IL1RN1/4 was 30.9% (79/256), 0.4% (1/256) and 1.2% (3/256) in Chinese Han, whereas only heterozygosity for IL-1RN1/2 was found in Chinese She (13.5%, 34/252). Frequencies of the most common allele IL-1RN1 and IL-1RN2 were 83.0% and 16.2% for Chinese Han and 93.3% and 6.7% for Chinese She respectively. The rare allele IL-1RN3 and IL-1RN4 was only observed in the Chinese Han population with the frequency of 0.2% and 0.6% respectively. Our findings suggested that the ethnic background plays an important role in IL-1Ra gene variation in different populations.
File Format	HTM / HTML
ISSN	17443121
Issue Number	1
Volume Number	38
e-ISSN	1744313X
Journal	International Journal of Immunogenetics
Language	English
Publisher	Wiley-Blackwell
Publisher Date	2011-02-01
Publisher Place	Great Britain (UK)
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Genetics Discipline Immunology Asian Continental Ancestry Group Genetics Interleukin 1 Receptor Antagonist Protein Minisatellite Repeats Polymorphism, Genetic China Ethnology Gene Frequency Genotype Humans Journal Article Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Genetics Molecular Biology Immunology Genetics (clinical)

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