NDLI: Allelic polymorphism of human FcÎ³RIIA-H/R131 receptor in American tegumentary leishmaniasis.

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Allelic polymorphism of human FcÎ³RIIA-H/R131 receptor in American tegumentary leishmaniasis.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Oliveira, C. R. Pereira, L. I. A. Pereira, A-J C. S. Ferreira, A. A. Crespo, A. M. C. Silveira, L. A.
Description	Country affiliation: Brazil Author Affiliation: Oliveira CR ( Setor de Imunologia, Instituto de Patologia Tropical e Saúde Pública, Universidade Federal de Goiás, Rua 235 s/n, Goiânia, Goiás, Brazil.)
Abstract	FcÎ³RIIA binding to IgG subclasses with different levels of affinity is influenced by the polymorphism in the gene that encodes this receptor. The substitution of arginine (R) for histidine (H) in the 131 position defines three allelic patterns, H/H, R/R, and H/R, resulting in FcÎ³RIIA-H/H131 affinity for IgG2 and higher affinity for IgG3 subclasses. Studies have shown the importance of genetic host factors in leishmaniasis and participation of FcÎ³Rs on the macrophage infection by amastigote forms and in the immune response to Leishmania sp. We analysed the influence of allelic diversity patterns of the receptor FcÎ³RIIA on American tegumentary leishmaniasis (ATL). FcÎ³RIIA-H/R131 polymorphism was determined by PCR followed by an allele-specific enzymatic digestion in 88 individuals with ATL and 98 healthy volunteer blood donors (control group). The genotypic and allelic distributions of FcÎ³RIIA-H/R131 were similar among the studied groups as well in mild and severe clinical forms of ATL. Our results suggest no association between this allelic polymorphism and susceptibility or resistance to ATL, neither influencing the development of different clinical forms of this illness.
File Format	HTM / HTML
ISSN	17443121
Issue Number	3
Volume Number	38
e-ISSN	1744313X
Journal	International Journal of Immunogenetics
Language	English
Publisher	Wiley-Blackwell
Publisher Date	2011-06-01
Publisher Place	Great Britain (UK)
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Genetics Discipline Immunology Leishmaniasis, Cutaneous Genetics Polymorphism, Genetic Receptors, Igg Adolescent Adult Aged Alleles Case-control Studies Child Female Gene Frequency Genotype Humans Male Middle Aged Young Adult Journal Article Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Genetics Molecular Biology Immunology Genetics (clinical)

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Allelic polymorphism of human FcÎ³RIIA-H/R131 receptor in American tegumentary leishmaniasis.

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