NDLI: Ciprofloxacin inhibits proliferation and synergistic effect against hepatocellular carcinoma cancer lines with cisplatin

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Ciprofloxacin inhibits proliferation and synergistic effect against hepatocellular carcinoma cancer lines with cisplatin

Content Provider	Semantic Scholar
Author	Fu, Yun Zhou, Sufeng Li, Zhaoquan Zhang, Yanfang Li, Shisheng Li, Changzheng
Copyright Year	2013
Abstract	Combination therapy has generated significant interest in the clinical setting since it increases the therapeutic potential of anticancer drugs. The potential therapeutic benefits in combination of cisplatin and ciprofloxacin have not been fully explored in hepatocellular carcinoma cancer therapy. In the results to be presented here, cellular viability of Hep G2 and Bel-7402 was determined by the 3-(4, 5dimethylthiazol-2-yl)-2,5-diphenyl-2H-tetrazolium bromide) (MTT) assay and the assessment of synergism, additivity or antagonism was carried out by the median effect analysis. Mechanism of cytotoxicity of the drugs was probed by reverse transcriptase-polymerase chain reaction (RT-PCR). Cellular DNA breaks were evaluated by comet assay. In addition, the effect of the drugs on topoisomerases was also investigated. The results show that ciprofloxacin could affect viability of Hep G2 and Bel-7402 lines, its combination with cisplatin resulted in mixed interactions; synergistic and additive effect. Further investigation indicated that the synergistic effect or additive was correlated to Fas involved apoptotic path, but the effects in combination on topoisomerases were not evident. The results obtained in this study suggest that the therapeutic benefit of cisplatin anti-hepatocellular carcinoma (HCC) may be influenced by ciprofloxacin.
File Format	PDF HTM / HTML
Alternate Webpage(s)	https://academicjournals.org/journal/AJPP/article-full-text-pdf/1462ACD26715
Language	English
Access Restriction	Open
Subject Keyword	Ciprofloxacin Cisplatin Comet Assay DNA Breaks Feedback arc set G2 Phase Cell Cycle Checkpoints Gnutella2 Human-centered computing INSPIRE-HEP Interaction Liver carcinoma Non-Small Cell Lung Carcinoma RNA-Directed DNA Polymerase Reverse Transcriptase Polymerase Chain Reaction Synergy Tetrazolium Salts USB hub Utility functions on indivisible goods benefit methscopolamine bromide monooxyethylene trimethylolpropane tristearate
Content Type	Text
Resource Type	Article

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