NDLI: Synergistic interaction between quercetin and doxorubicin on MCF-7 human breast cancer cell line

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Synergistic interaction between quercetin and doxorubicin on MCF-7 human breast cancer cell line

Content Provider	Semantic Scholar
Author	Purba, Abdul Khairul Rizki Mustofa Astuti, Indwiani
Copyright Year	2014
Abstract	The effectiveness of doxorubicin has decreased due to resistance of cancer cells. One of the natural ingredients that are proven to reduce the resistance to anticancer is quercetin. Quercetin interacts with doxorubicin via a competition of P-glycoprotein (P-gp) transporter activity. The aim of this study is to evaluate the interaction of quercetin and doxorubicin as cytotoxicity effect on MCF-7 cells. Cytotoxicity test was conducted by the MTT method. Mechanism of interaction between doxorubicin and quercetin was evaluated with isobologram analysis. Doxorubicin and quercetin inhibited the growth of MCF-7 cells significantly. Doxorubicin and quercetin respectively had IC50 of 21M and 103 M. The interaction of doxorubicin and quercetin were characterized by the amount of doxorubicin IC50 equivalent and quercetin IC50 equivalent less than 1 and the point-intercept of each IC50 notation equivalent plotted on the graph below the additive line. Analysis of isobolograms indicated that the interaction doxorubisn and quercetin in each of the ratios had synergy. Quercetin can be considered to be in a combination with doxorubicin. Further study to determine other mechanisms of the interaction is required.
File Format	PDF HTM / HTML
Alternate Webpage(s)	https://jurnal.ugm.ac.id/bik/article/download/5024/4184
Language	English
Access Restriction	Open
Subject Keyword	Breast Cancer Cell Cultured Cell Line Doxorubicin Graph - visual representation Inhibitory Concentration 50 Intercept Substance Mammary Neoplasms P-Glycoproteins Quercetin Synergy USB hub Utility functions on indivisible goods Visual Intercept monooxyethylene trimethylolpropane tristearate notation
Content Type	Text
Resource Type	Article

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