NDLI: Nickel-catalyzed allylic defluorinative alkylation of trifluoromethyl alkenes with reductive decarboxylation of redox-active esters† †Electronic supplementary information (ESI) available: Experimental protocols and spectral data. See DOI: 10.1039/c8sc04335c

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Nickel-catalyzed allylic defluorinative alkylation of trifluoromethyl alkenes with reductive decarboxylation of redox-active esters† †Electronic supplementary information (ESI) available: Experimental protocols and spectral data. See DOI: 10.1039/c8sc04335c

Content Provider	Semantic Scholar
Author	Wang, Xiaoxu Gong, Tian-Jun Pi, Jing-Jing He, Shi-Jiang
Copyright Year	2019
Abstract	Herein, we report a nickel-catalyzed allylic defluorinative alkylation of trifluoromethyl alkenes through reductive decarboxylation of redox-active esters. The present reaction enables the preparation of functionalized gem-difluoroalkenes with the formation of sterically hindered C(sp3)-C(sp3) bonds under very mild reaction conditions, while tolerating many sensitive functional groups and requiring minimal substrate protection. Therefore, this method provides an efficient and convenient approach for late-stage modification of biologically interesting molecules.
Starting Page	809
Ending Page	814
Page Count	6
File Format	PDF HTM / HTML
DOI	10.1039/c8sc04335c
PubMed reference number	30774875
Journal	Medline
Volume Number	10
Alternate Webpage(s)	https://pubs.rsc.org/en/content/articlepdf/2019/sc/c8sc04335c
Alternate Webpage(s)	http://www.rsc.org/suppdata/c8/sc/c8sc04335c/c8sc04335c1.pdf
Alternate Webpage(s)	https://doi.org/10.1039/c8sc04335c
Journal	Chemical science
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article

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