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Ni-catalysed reductive arylalkylation of unactivated alkenes† †Electronic supplementary information (ESI) available: Experimental procedure, spectral data, NMR-data, and HPLC-data. See DOI: 10.1039/c8sc04279a
| Content Provider | Semantic Scholar |
|---|---|
| Author | Jin, Youxiang Wang, Chuan |
| Copyright Year | 2019 |
| Abstract | In this protocol Ni-catalysed reductive arylalkylation of unactivated alkenes tethered to aryl bromides with primary alkyl bromides has been accomplished, providing a new path to construct diverse benzene-fused carbo- and heterocyclic cores including indanes, tetrahydroisoquinolines, indolines and isochromanes. Notably, this new method circumvents the pregeneration of organometallics and demonstrates high tolerance to a wide range of functional groups. The preliminary mechanistic investigations suggest a reaction pathway with an intermediate reduction. |
| Starting Page | 1780 |
| Ending Page | 1785 |
| Page Count | 6 |
| File Format | PDF HTM / HTML |
| DOI | 10.1039/c8sc04279a |
| PubMed reference number | 30842845 |
| Journal | Medline |
| Volume Number | 10 |
| Alternate Webpage(s) | https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/09/b2/SC-010-C8SC04279A.PMC6369408.pdf |
| Alternate Webpage(s) | https://doi.org/10.1039/c8sc04279a |
| Journal | Chemical science |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
