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Transcriptional control via translational repression by c4 antisense RNA of bacteriophages P1 and P7.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Biere, Armin Citron, Martin Schuster, Heinz |
| Copyright Year | 1992 |
| Abstract | The c4 repressors of bacteriophages P1 and P7 are antisense RNAs that inhibit antirepressor synthesis. This antisense inhibition is unusual in that the c4 repressor and the repressed genes orfx and ant are cotranscribed in that order from the same promoter, and c4 RNA is processed from a precursor RNA. Here, we show that c4 RNA directly represses translation of orfx, a small open reading frame, to which ant is translationally coupled. This translational repression blocks ant transcription via a rho-dependent terminator. Thus, c4 RNA controls expression of the ant gene by a novel indirect mechanism combining translational repression, translational coupling, and rho-dependent termination. |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | http://genesdev.cshlp.org/content/6/12a/2409.full.pdf |
| PubMed reference number | 1459462v1 |
| Volume Number | 6 |
| Issue Number | 12A |
| Journal | Genes & development |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Antisense RNA Bacteriophages Genetic Translation Process Open Reading Frames Post-Translational Protein Processing Reading Frames (Nucleotide Sequence) Repression, Psychology Transcription Repressor/Corepressor Transcriptional Regulation Translational Repression antisense therapy |
| Content Type | Text |
| Resource Type | Article |
