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Control of Fur synthesis by the non-coding RNA RyhB and iron-responsive decoding.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Vecerek, Branislav Moll, Isabella Blaesi, Udo |
| Copyright Year | 2007 |
| Abstract | The Fe2+-dependent Fur protein serves as a negative regulator of iron uptake in bacteria. As only metallo-Fur acts as an autogeneous repressor, Fe2+scarcity would direct fur expression when continued supply is not obviously required. We show that in Escherichia coli post-transcriptional regulatory mechanisms ensure that Fur synthesis remains steady in iron limitation. Our studies revealed that fur translation is coupled to that of an upstream open reading frame (uof), translation of which is downregulated by the non-coding RNA (ncRNA) RyhB. As RyhB transcription is negatively controlled by metallo-Fur, iron depletion creates a negative feedback loop. RyhB-mediated regulation of uof-fur provides the first example for indirect translational regulation by a trans-encoded ncRNA. In addition, we present evidence for an iron-responsive decoding mechanism of the uof-fur entity. It could serve as a backup mechanism of the RyhB circuitry, and represents the first link between iron availability and synthesis of an iron-containing protein. |
| Starting Page | P8 |
| Ending Page | P8 |
| Page Count | 1 |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | http://embojnl.embopress.org/content/embojnl/26/4/965.full.pdf |
| PubMed reference number | 17268550v1 |
| Volume Number | 26 |
| Issue Number | 4 |
| Journal | The EMBO journal |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Bacteria Ferrous Genetic Translation Process Open Reading Frames RNA RNA, Untranslated Reading Frames (Nucleotide Sequence) Transcription, Genetic Translational Regulation non-T, non-B childhood acute lymphoblastic leukemia |
| Content Type | Text |
| Resource Type | Article |
