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Sustainable ppm level palladium-catalyzed aminations in nanoreactors under mild, aqueous conditions† †Electronic supplementary information (ESI) available. See DOI: 10.1039/c9sc03710a
| Content Provider | Semantic Scholar |
|---|---|
| Author | Zhang, Yitao Takale, Balaram S. Gallou, Fabrice Reilly, John Lipshutz, Bruce H. |
| Copyright Year | 2019 |
| Abstract | A 1 : 1 Pd : ligand complex, [t-BuXPhos(Pd-π-cinnamyl)]OTf, has been identified as a highly robust pre-catalyst for amination reactions leading to diarylamines, where loadings of metal are typically at 1000 ppm Pd, run in water at temperatures between rt and 45 °C. The protocol is exceptionally simple, is readily scaled, and compares very favorably vs. traditional amination conditions. It has also been shown to successfully lead to key intermediates associated with several physiologically active compounds. |
| Starting Page | 10556 |
| Ending Page | 10561 |
| Page Count | 6 |
| File Format | PDF HTM / HTML |
| DOI | 10.1039/c9sc03710a |
| PubMed reference number | 32110341 |
| Journal | Medline |
| Volume Number | 10 |
| Alternate Webpage(s) | http://www.rsc.org/suppdata/c9/sc/c9sc03710a/c9sc03710a1.pdf |
| Alternate Webpage(s) | https://doi.org/10.1039/c9sc03710a |
| Journal | Chemical science |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
