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Cobalt-catalyzed hydroxymethylarylation of terpenes with formaldehyde and arenes† †Electronic supplementary information (ESI) available. See DOI: 10.1039/c9sc03747k
| Content Provider | Semantic Scholar |
|---|---|
| Author | Yang, Jun Ji, Ding-Wei Hu, Yancheng Min, Xiang-Ting Zhou, Xiangge Chen, Qing-An |
| Copyright Year | 2019 |
| Abstract | Terpenes, consisting of isoprene monomer units, represent a family of naturally abundant compounds. The difunctionalization of terpenes is highly appealing yet remains challenging, since the multiple unbiased C[double bond, length as m-dash]C bonds of terpenes lead to difficulty in controlling the regioselectivity. Herein, a cobalt(iii)-catalyzed C-H activation strategy has been developed to facilitate hydroxymethylarylation of terpenes with formaldehyde and arenes with high chemo- and regio-selectivities. These (chemo- and regio-) selectivities are governed by the coordination abilities of isoprene, directing groups and the steric effect. This terpene difunctionalization also features high atom and step economy through a C-H addition pathway. |
| Starting Page | 9560 |
| Ending Page | 9564 |
| Page Count | 5 |
| File Format | PDF HTM / HTML |
| DOI | 10.1039/c9sc03747k |
| PubMed reference number | 32055328 |
| Journal | Medline |
| Volume Number | 10 |
| Alternate Webpage(s) | http://www.rsc.org/suppdata/c9/sc/c9sc03747k/c9sc03747k1.pdf |
| Alternate Webpage(s) | https://doi.org/10.1039/c9sc03747k |
| Journal | Chemical science |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
