NDLI: A Syndrome of Peripheral Blood T-Cell Infection With Epstein-Barr Virus (EBV) Followed by EBV–Positive T-Cell Lymphoma

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A Syndrome of Peripheral Blood T-Cell Infection With Epstein-Barr Virus (EBV) Followed by EBV–Positive T-Cell Lymphoma

Content Provider	Scilit
Author	Kanegane, Hirokazu Bhatia, Kishor Gutierrez, Marina Kaneda, Hisashi Wada, Taizo Yachie, Akihiro Seki, Hidetoshi Arai, Takashi Kagimoto, Sei-Ichi Okazaki, Minoru Oh-Ishi, Tsutomu Moghaddam, Amir Wang, Fred Tosato, Giovanna
Copyright Year	1998
Description	The role of Epstein-Barr virus (EBV) in the pathogenesis of severe, chronic active EBV infection and its complications is unclear. We investigated two Japanese patients diagnosed with severe, chronic active EBV infection who subsequently developed EBV–positive T-cell lymphoma. The patients displayed abnormally high antibody titers to EBV antigens, and had evidence of peripheral blood CD4+T-cell infection with EBV, 19 months and 3 months, respectively, before the diagnosis of EBV–positive T-cell lymphoma. The lymphomas were infected with monoclonal EBV and expressed the EBV latency genes EBNA-1, LMP-1, and LMP-2. Genetic studies showed that the virus detected in the T-cell lymphoma was indistinguishable, with respect to type and previously defined LMP-1 and EBNA-1 gene variations, from virus detected in the peripheral blood T cells 19 months earlier. These studies support an important pathogenetic role of T-cell infection with EBV in chronic active EBV infection and in the EBV–positive T-cell lymphoma that followed.
Related Links	https://ashpublications.org/blood/article-pdf/91/6/2085/768891/2085.pdf
Ending Page	2091
Page Count	7
Starting Page	2085
DOI	10.1182/blood.v91.6.2085
Journal	Blood
Issue Number	6
Volume Number	91
Language	English
Publisher	American Society of Hematology
Publisher Date	1998-03-15
Access Restriction	Open
Subject Keyword	Infectious Diseases Antibody Virus Antigens Lymphoma Epstein Barr Chronic Active Ebv Infection Journal: Blood (Vol- 90, Issue- 6)
Content Type	Text
Resource Type	Article

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