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Chronic Active Epstein–Barr Virus Infection: The Elucidation of the Pathophysiology and the Development of Therapeutic Methods
| Content Provider | MDPI |
|---|---|
| Author | Arai, Ayako |
| Copyright Year | 2021 |
| Description | Chronic active Epstein–Barr virus infection (CAEBV) is a disease where Epstein–Barr virus (EBV)-infected T- or NK-cells are activated and proliferate clonally. The symptoms of this dual-faced disease include systemic inflammation and multiple organ failures caused by the invasion of infected cells: inflammation and neoplasm. At present, the only effective treatment strategy to eradicate EBV-infected cells is allogeneic stem cell transplantation. Lately, the investigation into the disease’s pathogenic mechanism and pathophysiology has been advancing. In this review, I will evaluate the new definition in the 2017 WHO classification, present the advancements in the study of CAEBV, and unfold the future direction. |
| Starting Page | 180 |
| e-ISSN | 20762607 |
| DOI | 10.3390/microorganisms9010180 |
| Journal | Microorganisms |
| Issue Number | 1 |
| Volume Number | 9 |
| Language | English |
| Publisher | MDPI |
| Publisher Date | 2021-01-15 |
| Access Restriction | Open |
| Subject Keyword | Microorganisms Cell Tissue Engineering Systemic Chronic Active Epstein–barr Virus Infection Cutaneous Chronic Active Epstein–barr Virus Infection Ebv-positive T-cell Lymphoma of Childhood Who Classification |
| Content Type | Text |
| Resource Type | Article |
