NDLI: A syndrome of peripheral blood T-cell infection with Epstein-Barr virus (EBV) followed by EBV-positive T-cell lymphoma.

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A syndrome of peripheral blood T-cell infection with Epstein-Barr virus (EBV) followed by EBV-positive T-cell lymphoma.

Content Provider	Semantic Scholar
Author	Kanegane, Hirokazu Bhatia, K. Gutierrez, M. Kaneda, Hideaki Wada, Tomoyuki Yachie, Akihiro Seki, Hidetoshi Arai, T. Kagimoto, Seiiti Okazaki, Minoru Oh-Ishi, T. Moghaddam, Arash Wang, Fu-Hsiung Tosato, Giovanna
Copyright Year	1998
Abstract	The role of Epstein-Barr virus (EBV) in the pathogenesis of severe, chronic active EBV infection and its complications is unclear. We investigated two Japanese patients diagnosed with severe, chronic active EBV infection who subsequently developed EBV-positive T-cell lymphoma. The patients displayed abnormally high antibody titers to EBV antigens, and had evidence of peripheral blood CD4(+) T-cell infection with EBV, 19 months and 3 months, respectively, before the diagnosis of EBV-positive T-cell lymphoma. The lymphomas were infected with monoclonal EBV and expressed the EBV latency genes EBNA-1, LMP-1, and LMP-2. Genetic studies showed that the virus detected in the T-cell lymphoma was indistinguishable, with respect to type and previously defined LMP-1 and EBNA-1 gene variations, from virus detected in the peripheral blood T cells 19 months earlier. These studies support an important pathogenetic role of T-cell infection with EBV in chronic active EBV infection and in the EBV-positive T-cell lymphoma that followed.
File Format	PDF HTM / HTML
DOI	10.1182/blood.v91.6.2085.2085_2085_2091
PubMed reference number	9490694
Journal	Medline
Volume Number	91
Issue Number	6
Alternate Webpage(s)	http://www.bloodjournal.org/content/bloodjournal/91/6/2085.full.pdf?sso-checked=true
Alternate Webpage(s)	https://doi.org/10.1182/blood.v91.6.2085.2085_2085_2091
Journal	Blood
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article

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