NDLI: Atypical prediagnosis Epstein-Barr virus serology restricted to EBV-positive Hodgkin lymphoma

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Atypical prediagnosis Epstein-Barr virus serology restricted to EBV-positive Hodgkin lymphoma

Content Provider	Scilit
Author	Levin, Lynn I. Chang, Ellen T. Ambinder, Richard F. Lennette, Evelyne T. Rubertone, Mark V. Mann, Risa B. Borowitz, Michael Weir, Edward G. Abbondanzo, Susan L. Mueller, Nancy E.
Copyright Year	2012
Description	An altered anti–Epstein-Barr virus (EBV) serologic profile preceding diagnosis is associated with an increased risk of Hodgkin lymphoma. It is unknown whether this atypical pattern predicts Hodgkin lymphoma risk further subdivided by determination of EBV in tumor cells. A nested case-control study of 128 incident Hodgkin lymphoma cases and 368 matched controls from active-duty military personnel with archived serum in the US Department of Defense Serum Repository was conducted to determine whether a panel of anti-EBV antibody titers differed in EBV+ and EBV− Hodgkin lymphoma. Among 40 EBV+ Hodgkin lymphoma cases and matched controls, statistically significant increased risks were associated with elevated anti-EBV VCA IgG antibody titers (relative risk = 3.1; 95% confidence interval [CI], 1.1-8.7), and an anti–EBNA-1/anti–EBNA-2 antibody ratio ≤ 1.0 versus > 1.0 (relative risk = 4.7; 95% CI, 1.6-13.8). In contrast, no significant associations were found among 88 EBV− Hodgkin lymphoma cases relative to their matched controls. In case-case analysis, EBV+ disease was significantly associated with a low anti–EBNA-1/anti–EBNA-2 antibody ratio. This distinc-tive serologic response to EBV latent antigens, indicative of immune dysfunction in other clinical settings, is associated with an increased risk of developing EBV+ but not EBV− Hodgkin lymphoma.
Related Links	http://www.bloodjournal.org/content/bloodjournal/120/18/3750.full.pdf
Ending Page	3755
Page Count	6
Starting Page	3750
DOI	10.1182/blood-2011-12-390823
Journal	Blood
Issue Number	18
Volume Number	120
Language	English
Publisher	American Society of Hematology
Publisher Date	2012-11-01
Access Restriction	Open
Subject Keyword	Virology Antibody Virus Antigens Hodgkin Lymphoma Ebna Ebv Serologic Journal: Blood (Vol- 129, Issue- 18)
Content Type	Text
Resource Type	Article

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